JaLCDOI 10.18926/AMO/31858
フルテキストURL fulltext.pdf
著者 Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao|
抄録 <p>Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this &#34;11R&#34;, all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).</p>
キーワード cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP)
Amo Type Review
発行日 2009-02
出版物タイトル Acta Medica Okayama
63巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 7
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 19247417
Web of Science KeyUT 000263730300001
タイトル(別表記) Novel protein transduction method for cerebral arteries using 11R
フルテキストURL 120_129.pdf
著者 小川 智之| 小野 成紀| 市川 智継| 有光 帥二| 小野田 惠介| 徳永 浩司| 杉生 憲志| 富澤 一仁| 松井 秀樹| 伊達 勲|
キーワード cerebral vasospasm 11R protein transduction method
出版物タイトル 岡山医学会雑誌
発行日 2008-08-01
120巻
2号
開始ページ 129
終了ページ 133
ISSN 00301558
言語 Japanese
著作権者 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.120.129
NAID 120002310545
フルテキストURL 118_205.pdf
著者 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲|
キーワード プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン
出版物タイトル 岡山医学会雑誌
発行日 2007-01-04
118巻
3号
開始ページ 205
終了ページ 208
ISSN 00301558
言語 Japanese
著作権者 Copyright© 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma1947.118.3_205
NAID 10018454083
著者 市川 智継| 黒住 和彦| 伊達 勲|
発行日 2008-12-01
出版物タイトル 岡山医学会雑誌
120巻
3号
資料タイプ 学術雑誌論文
著者 Kosaka, H| Ichikawa, T| Kurozumi, K| Kambara, H| Inoue, S| Maruo, T| Nakamura, K| Hamada, H| Date, I|
発行日 2012-08
出版物タイトル Cancer Gene Therapy
19巻
8号
資料タイプ 学術雑誌論文
著者 Iwado, Eiji| Ichikawa, Tomotsugu| Kosaka, Hiroshi| Otsuka, Shinji| Kambara, Hirokazu| Tamiya, Takashi| Kondo, Seiji| Date, Isao|
発行日 2012-12
出版物タイトル Neuropathology
32巻
6号
資料タイプ 学術雑誌論文
著者 Maruo, Tomoko| Ichikawa, Tomotsugu| Kanzaki, Hirotaka| Inoue, Satoshi| Kurozumi, Kazuhiko| Onishi, Manabu| Yoshida, Koichi| Kambara, Hirokazu| Ouchida, Mamoru| Shimizu, Kenji| Tamaru, Seiji| Chiocca, E. Antonio| Date, Isao|
発行日 2013-06
出版物タイトル Neuropathology
33巻
3号
資料タイプ 学術雑誌論文
著者 Onishi, Manabu| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Fujii, Kentaro| Yoshida, Koichi| Inoue, Satoshi| Michiue, Hiroyuki| Chiocca, E. Antonio| Kaur, Balveen| Date, Isao|
発行日 2013-04
出版物タイトル Neuropathology
33巻
2号
資料タイプ 学術雑誌論文
著者 Ishida, Joji| Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Fujii, Kentaro| Shimazu, Yosuke| Oka, Tetsuo| Date, Isao|
発行日 2014-04
出版物タイトル Translational Oncology
7巻
2号
資料タイプ 学術雑誌論文
著者 Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao|
発行日 2013-04-15
出版物タイトル SpringerPlus
2巻
資料タイプ 学術雑誌論文
フルテキストURL fulltext.pdf
著者 Tomita, Yusuke| Fujii, Kentaro| 0000-0002-6942-9919| Imoto, Ryoji| Mitsui, Takashi| Mishima, Sakurako| Inagaki, Kenichi| Masuyama, Hisashi| Date, Isao|
キーワード Optic nerve Cavernous hemangioma Pregnant Visual evoked potential
発行日 2019-12-31
出版物タイトル Interdisciplinary Neurosurgery
18巻
出版者 Elsevier
開始ページ 100489
ISSN 22147519
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier B.V.
論文のバージョン publisher
DOI 10.1016/j.inat.2019.100489
Web of Science KeyUT 000499495300012
関連URL isVersionOf https://doi.org/10.1016/j.inat.2019.100489
JaLCDOI 10.18926/AMO/32888
フルテキストURL fulltext.pdf
著者 Yasuhara, Takao| Shingo, Tetsuro| Date, Isao|
抄録 <p>Many studies using animals clarify that glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic neurons. Several pilot studies clarified the validity of continuous intraputaminal GDNF infusion to patients with Parkinson's disease (PD), although a randomized controlled trial of GDNF therapy published in 2006 resulted in negative outcomes, and controversy remains about the efficacy and safety of the treatment. For a decade, our laboratory has investigated the efficacy and the most appropriate method of GDNF administration using animals, and consequently we have obtained some solid data that correspond to the results of clinical trials. In this review, we present an outline of our studies and other key studies related to GDNF, the current state of the research, problems to be overcome, and predictions regarding the use of GDNF therapy for PD in the future.</p>
キーワード cell transplantation clinical trial encapsulation gene therapy neurodegenerative disease
Amo Type Review
発行日 2007-04
出版物タイトル Acta Medica Okayama
61巻
2号
出版者 Okayama University Medical School
開始ページ 51
終了ページ 56
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 17471304
Web of Science KeyUT 000245875600001
JaLCDOI 10.18926/AMO/43832
フルテキストURL 65_1_59.pdf
著者 Yasuhara, Takao| Miyoshi, Yasuyuki| Date, Isao|
抄録 A case of a Chiari malformation with an extraordinarily thick occipital bone is described. The thick occipital bone might make the posterior fossa narrow with consequent herniation of the cerebellar tonsils to the foramen magnum and formation of a syrinx. At dural plasty, well-developed marginal and occipital sinuses should be deliberately handled with the preservation of normal venous drainage. This case gives us the essence of the occurrence mechanisms of Chiari malformation and foramen magnum decompression.
キーワード Chiari malformation dural plasty foramen magnum decompression syrinx venous drainage
Amo Type Case Report
発行日 2011-02
出版物タイトル Acta Medica Okayama
65巻
1号
出版者 Okayama University Medical School
開始ページ 59
終了ページ 61
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21339798
Web of Science KeyUT 000287620500009
JaLCDOI 10.18926/AMO/48962
フルテキストURL 66_6_429.pdf
著者 Wang, Feifei| Maeda, Nagamasa| Yasuhara, Takao| Kameda, Masahiro| Tsuru, Emi| Yamashita, Tatsuyuki| Shen, Yuan| Tsuda, Masayuki| Date, Isao| Sagara, Yusuke|
抄録 Human umbilical cord blood (HUCB) cells are rich source of immature stem cells, which have the potential to repair lost tissue. Intractable central nervous system (CNS) disorders are important targets for regenerative medicine, and the application of HUCB cells is being investigated in animal models of CNS disorders. Transplantation of HUCB has induced functional improvements in these animal models due to multiple therapeutic effects including neuroprotection, anti-inflammation, angiogenesis, and neurogenesis. HUCB cells are easily available and safer than other stem cells used in transplantation therapy. In this review, we focus on HUCB transplantation as an encouraging therapeutic approach for animal models of neonatal hypoxic-ischemic brain injury and ischemic stroke.
キーワード umbilical cord blood cell transplantation neonatal hypoxic-ischemic brain injury ischemic stroke stem cells
Amo Type Review
発行日 2012-12
出版物タイトル Acta Medica Okayama
66巻
6号
出版者 Okayama University Medical School
開始ページ 429
終了ページ 434
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23254576
Web of Science KeyUT 000312966100001
JaLCDOI 10.18926/AMO/49045
フルテキストURL 66_6_487.pdf
著者 Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao|
抄録 We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy.
キーワード periventricular nodular heterotopia epilepsy surgery ictal electroencephalography
Amo Type Case Report
発行日 2012-12
出版物タイトル Acta Medica Okayama
66巻
6号
出版者 Okayama University Medical School
開始ページ 487
終了ページ 492
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 23254583
Web of Science KeyUT 000312966100008
JaLCDOI 10.18926/AMO/54497
フルテキストURL 70_4_229.pdf
著者 Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao|
抄録 About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD.
キーワード clinical research moyamoya disease
Amo Type Review
発行日 2016-08
出版物タイトル Acta Medica Okayama
70巻
4号
出版者 Okayama University Medical School
開始ページ 229
終了ページ 236
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27549666
Web of Science KeyUT 000384748600001
JaLCDOI 10.18926/AMO/55201
フルテキストURL 71_3_191.pdf
著者 Kobayashi, Katsuhiro| Akiyama, Tomoyuki| Agari, Takashi| Sasaki, Tatsuya| Shibata, Takashi| Hanaoka, Yoshiyuki| Akiyama, Mari| Endoh, Fumika| Oka, Makio| Date, Isao|
抄録  Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (< 0.1 Hz) to traditional frequency bands (e.g., the approx. 10 Hz alpha rhythm) to high-frequency bands of up to 500 Hz. High-frequency oscillations (HFOs) including ripple and fast ripple oscillations (80-200 Hz and>200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding.
キーワード fast oscillations, epilepsy electroencephalogram time-frequency analysis
Amo Type Review
発行日 2017-06
出版物タイトル Acta Medica Okayama
71巻
3号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 200
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655938
フルテキストURL Acta_Neurochir_159_7_1329.pdf
著者 Kidani, Naoya| Sugiu, Kenji| Hishikawa, Tomohito| Hiramatsu, Masafumi| Haruma, Jun| Nishihiro, Shingo| Takahashi, Yu| Date, Isao|
キーワード De novo aneurysm Hemodynamic stress Stent-assisted coil embolization Vertebral artery dissecting aneurysm
発行日 2017-07
出版物タイトル Acta Neurochirurgica
159巻
7号
出版者 Springer
開始ページ 1329
終了ページ 1333
ISSN 00016268
NCID AA0050885X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28493024
Web of Science KeyUT 000403508400024
関連URL https://doi.org/10.1007/s00701-017-3204-2
著者 Hishikawa, Tomohito| Sugiu, Kenji| Murai, Satoshi| Takahashi, Yu| Kidani, Naoya| Nishihiro, Shingo| Hiramatsu, Masafumi| Date, Isao| Satow, Tetsu| Iihara, Koji| Sakai, Nobuyuki| JR-NET2 and JR-NET3 study groups.|
キーワード Complication Embolization Intracranial tumor Risk factors
備考 This fulltext will be available in Aug 2020|
発行日 2019-06-07
出版物タイトル Acta Neurochirurgica
161巻
8号
出版者 Springer Nature
開始ページ 1675
終了ページ 1682
ISSN 00016268
NCID AA0050885X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31172282
DOI 10.1007/s00701-019-03970-w
Web of Science KeyUT 000475688800023
関連URL isVersionOf https://doi.org/10.1007/s00701-019-03970-w
フルテキストURL fulltext.pdf
著者 Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Otani, Yoshihiro| Fujimura, Atsushi| Fujii, Kentaro| Tomita, Yusuke| Hattori, Yasuhiko| Uneda, Atsuhito| Tsuboi, Nobushige| Kaneda, Keisuke| Makino, Keigo| Date, Isao|
キーワード ANXA2 OSMR Invasion Mesenchymal transition Glioblastoma
発行日 2020-04-05
出版物タイトル Acta Neuropathologica Communications
8巻
1号
出版者 BMC
開始ページ 42
ISSN 2051-5960
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 32248843
DOI 10.1186/s40478-020-00916-7
Web of Science KeyUT 000524286500001
関連URL isVersionOf https://doi.org/10.1186/s40478-020-00916-7