フルテキストURL BD_40_9_781_785.pdf BD_40_9_Fig.pdf
著者 Miyahara, Hiroyuki| Akiyama, Tomoyuki| Waki, Kenji| Arakaki, Yoshio|
キーワード Prolonged febrile seizure Acute encephalopathy with biphasic seizures and late reduced diffusion Venous blood gas analysis Electroencephalogram Clinical characteristics Venous blood gas
発行日 2018-01-14
出版物タイトル Brain and Development
40巻
9号
出版者 Elsevier
開始ページ 781
終了ページ 785
ISSN 0387-7604
NCID AA00111153
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2018 The Japanese Society of Child Neurology
論文のバージョン author
PubMed ID 29866486
DOI 10.1016/j.braindev.2018.05.014
Web of Science KeyUT 000445444200007
関連URL isVersionOf https://doi.org/10.1016/j.braindev.2018.05.014
著者 Miyahara, Hiroyuki| Akiyama, Tomoyuki| Hasegawa, Kosei| Akiyama, Mari| Oka, Makio| Kobayashi, Katsuhiro| Tsukahara, Hirokazu|
キーワード adrenocorticotropic hormone therapy calcium crystal renal tubular epithelial cell urinary sediment
備考 This is the peer reviewed version of the following article: Miyahara, Hiroyuki et.al. "Laboratory changes during adrenocorticotropic hormone therapy associated with renal calcified lesions" Pediatrics International 62(5) 587-592 (2020), which has been published in final form at https://doi.org/10.1111/ped.14158. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. </br>This fulltext is available in Jun. 2021.|
発行日 2020-01-19
出版物タイトル Pediatrics International
62巻
5号
出版者 Wiley
開始ページ 587
終了ページ 592
ISSN 1328-8067
NCID AA11320483
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2020 Japan Pediatric Society
論文のバージョン author
PubMed ID 31957090
DOI 10.1111/ped.14158
Web of Science KeyUT 000536494300014
関連URL isVersionOf https://doi.org/10.1111/ped.14158
フルテキストURL MGM_fulltext.pdf MGM_Fig1.tif MGM_Fig2.tif MGM_Fig3.tiff MGM_SuppleFig1.tif MGM_SuppleFig2.tif
著者 Akiyama, Tomoyuki| Kubota, Takuo| Ozono, Keiichi| Michigami, Toshimi| Kobayashi, Daisuke| Takeyari, Shinji| Sugiyama, Yuichiro| Noda, Masahiro| Harada, Daisuke| Namba, Noriyuki| Suzuki, Atsushi| Utoyama, Maiko| Kitanaka, Sachiko| Uematsu, Mitsugu| Mitani, Yusuke| Matsunami, Kunihiro| Takishima, Shigeru| Ogawa, Erika| Kobayashi, Katsuhiro|
キーワード Asfotase alfa Liquid chromatography Vitamin B6 Diagnostic marker Therapeutic monitoring
発行日 2018-07-17
出版物タイトル Molecular Genetics and Metabolism
125巻
1-2号
出版者 Elsevier
開始ページ 174
終了ページ 180
ISSN 10967192
NCID AA11158931
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 30049651
DOI 10.1016/j.ymgme.2018.07.006
Web of Science KeyUT 000447682900022
関連URL isVersionOf https://doi.org/10.1016/j.ymgme.2018.07.006
著者 Akiyama, Tomoyuki| Toda, Soichiro| Kimura, Nobusuke| Mogami, Yukiko| Tokorodani, Chiho| Ito, Tomoshiro| Miyahara, Hiroyuki| Hyodo, Yuki| Kobayashi, Katsuhiro|
キーワード AESD Biomarker Febrile seizure Pyridoxal 5′-phosphate Pyridoxal kinase Risk factor
備考 This fulltext is available in June 2021.|
発行日 2020-05
出版物タイトル Brain and Development
42巻
5号
出版者 Elsevier
開始ページ 402
終了ページ 407
ISSN 03877604
NCID AA00111153
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 32107100
DOI 10.1016/j.braindev.2020.02.002
Web of Science KeyUT 000527287200005
関連URL isVersionOf https://doi.org/10.1016/j.braindev.2020.02.002
JaLCDOI 10.18926/AMO/57955
フルテキストURL 74_1_65.pdf
著者 Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro|
抄録 To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
キーワード antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics
Amo Type Original Article
発行日 2020-02
出版物タイトル Acta Medica Okayama
74巻
1号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 72
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099251
フルテキストURL fulltext.pdf
著者 Yokoi, Katsuyuki| Nakajima, Yoko| Shinkai, Yasuko| Sano, Yoshimi| Imamura, Mototaka| Akiyama, Tomoyuki| Yoshikawa, Tetsushi| Ito, Tetsuya| Kurahashi, Hiroki|
キーワード ALPL Dominant-negative mutations Hypophosphatasia Premature loss of deciduous
発行日 2019-12-31
出版物タイトル Molecular Genetics and Metabolism Reports
21巻
出版者 Elsevier
開始ページ 100515
ISSN 22144269
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2019 The Authors. Published by Elsevier Inc.
論文のバージョン publisher
PubMed ID 31641588
DOI 10.1016/j.ymgmr.2019.100515
Web of Science KeyUT 000500718300013
関連URL isVersionOf https://doi.org/10.1016/j.ymgmr.2019.100515