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ID 30766
JaLCDOI
フルテキストURL
著者
Iwagaki, Hiromi Okayama University
Hizuta, Akio Okayama University
Uomoto, Masashi Okayama University
Takeuchi, Yoshiaki Okayama University
Tanaka, Noriaki Okayama University
抄録

Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia.

キーワード
cancer cachexia
neuro-endocrine-immune interactio
serotonin
neopterin
cortisol
Amo Type
Article
発行日
1997-08
出版物タイトル
Acta Medica Okayama
51巻
4号
出版者
Okayama University Medical School
開始ページ
233
終了ページ
236
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT