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ID 30790
JaLCDOI
フルテキストURL
著者
Nanba, Yoshifumi Okayama University
Nishida, Keiichiro Okayama University Kaken ID researchmap
Yoshikawa, Takeshi Okayama University
Sato, Toru Okayama University
Inoue, Hajime Okayama University
Kuboki, Yoshinori Hokkaido University
抄録

The expression of osteonectin (ON) in osteoarthritic articular cartilage was investigated by enzyme immunohistochemistry and colloidal gold immunoelectron microscopy. A total of 96 specimens from 9 knees of 8 patients with osteoarthritis (OA) were examined. In OA cartilage, ON-positive cells varied in distribution and were not seen in all the specimens obtained from the same patient. However, in over half of the specimens (56 of 96), especially in the specimens of Mankin's grades from 4 to 9, which corresponds to relatively early stages of OA, ON was expressed in the cartilage above the calcified layer. On the other hand, ON was detected only in the calcified layer below the tidemark in normal articular cartilage. In addition, colloidal gold immunoelectron microscopy revealed ON in chondrocytes and matrix vesicles (MVs). These findings suggest that ON acts through MVs in the early stages of OA as a significant pathogenetic factor involved in intracartilage calcification, which is known to have a close relationship to the progression of OA.

キーワード
chondrocalcinosis
osteoarthritis
osteonection
Mankin's histologic-histochemical grading
calcification
Amo Type
Article
発行日
1997-10
出版物タイトル
Acta Medica Okayama
51巻
5号
出版者
Okayama University Medical School
開始ページ
239
終了ページ
243
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT