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ID 30384
JaLCDOI
フルテキストURL
著者
Nishida, Keiichiro Okayama University Kaken ID researchmap
Inoue, Hajime Okayama University
Toda, Kazukiyo Okayama Univresity
Murakami, Takuro Okayama University
抄録

Localization of the glycosaminoglycans (GAG) was examined in the synovial membranes of patients with osteoarthritis under light microscopy using a fine cationic colloidal iron staining method combined with enzymatic digestion. Our staining method was very useful for demonstrating the difference in the localization of GAG in regions of the inflammatory site in the osteoarthritic synovial membrane. Hyaluronic acid was mainly located in connective tissues in the surface intercellular and perivascular spaces, chondroitin sulfate A/C in the highly fibrous part of and connective tissue around blood vessels, dermatan sulfate (chondroitin sulfate B) in the subsurface interstitium and vascular endothelial cells and heparan sulfate in part of vascular endothelial cells. No keratan sulfate was detected. GAG is reported to have an important role in cell movement, adherence and aggregation in the inflammatory sites. These findings should be useful for understanding the role of GAG in physiological and pathologic processes of secondary synovitis.

キーワード
glycosaminoglycan
synovial tissue
osteoarthritis
fine cationic colloidal iron
Amo Type
Article
発行日
1995-12
出版物タイトル
Acta Medica Okayama
49巻
6号
出版者
Okayama University Medical School
開始ページ
287
終了ページ
294
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT