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ID 52783
フルテキストURL
著者
Kurahashi, Hiroaki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Watanabe, Masami Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol Kaken ID publons researchmap
Sugimoto, Morito Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Ariyoshi, Yuichi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Mahmood, Sabina Okayama Univ, Okayama Univ Hosp, Ctr Innovat Clin Med
Araki, Motoo Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol ORCID Kaken ID publons researchmap
Ishii, Kazushi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol
Nasu, Yasutomo Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol Kaken ID publons researchmap
Nagai, Atsushi Kawasaki Med Univ, Dept Urol
Kumon, Hiromi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol Kaken ID publons
抄録
Gender identity disorder (GID) results from a disagreement between a person's biological sex and the gender to which he or she identifies. With respect to the treatment of female to male GID, testosterone replacement therapy (TRT) is available. The uric acid (UA) level can be influenced by testosterone; however, the early effects and dose-dependency of TRT on the serum UA concentration have not been evaluated in this population. We herein conducted a dose-response analysis of TRT in 160 patients with female to male GID. The TRT consisted of three treatment groups who received intramuscular injections of testosterone enanthate: 125 mg every two weeks, 250 mg every three weeks and 250 mg every two weeks. Consequently, serum UA elevation was observed after three months of TRT and there was a tendency toward testosterone dose-dependency. The onset of hyperuricemia was more prevalent in the group who received the higher dose. We also demonstrated a positive correlation between increased levels of serum UA and serum creatinine. Since the level of serum creatinine represents an individual's muscle volume and the muscle is a major source of purine, which induces UA upregulation, the serum UA elevation observed during TRT is at least partially attributed to an increase in muscle mass. This is the first study showing an association between serum UA elevation and a TRT-induced increase in muscle mass. The current study provides important information regarding TRT for the follow-up and management of the serum UA levels in GID patients.
キーワード
Gender identity disorder
Testosterone
Uric acid
Creatinine
Muscle
発行日
2013-12
出版物タイトル
Endocrine Journal
60巻
12号
開始ページ
1321
終了ページ
1327
ISSN
0918-8959
資料タイプ
学術雑誌論文
言語
English
著作権者
©The Japan Endocrine Society
論文のバージョン
publisher
査読
有り
DOI
Web of Science KeyUT