JaLCDOI 10.18926/AMO/32022
フルテキストURL fulltext.pdf
著者 Liu, Li| Aya, Kunihiko| Tanaka, Hiroyuki| Shimizu, Junya| Ito, Shigeru| Seino, Yoshiki|
抄録 <p>Nephrin, a gene product of the congenital nephrotic syndrome of the Finnish type (NPHS1), is a 1242-residue putative transmembrane protein of the immunoglobulin family of cell adhesion molecules. The expression of this gene is localized in rat and human glomerular epithelial cells. Here we report the expression of nephrin in various tissues other than the kidneys in mice. The expression of nephrin mRNA in various tissues of mice, including the kidneys, testes, spleen, thymus and brain, were first investigated by the RT-PCR method, and it was shown that a high level of nephrin mRNA could be detected in the testes of mice 1-6 weeks old. In situ hybridization revealed the expression of the nephrin gene in the Sertoli cells. Additionally, immunofluorescent staining studies indicated that nephrin was colocalized with anchoring protein ZO-1 in the mouse testis. From these results, it is inferred that nephrin is an important component of the barrier system in testes.</p>
キーワード nephrin Sertoli cells glomerular epithelial cells blood barrier
Amo Type Article
発行日 2001-06
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 161
終了ページ 165
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11434428
Web of Science KeyUT 000169512600002
著者 綾 邦彦|
発行日 1997-12-25
出版物タイトル 岡山医学会雑誌
資料タイプ 学術雑誌論文
著者 綾 邦彦|
発行日 1997-09-30
資料タイプ 学位論文