JaLCDOI 10.18926/AMO/31706
フルテキストURL fulltext.pdf
著者 Shibakura, Misako| Niiya, Kenji| Kiguchi, Toru| Nakata, Yasunari| Tanimoto, Mitsune|
抄録 <p>We previously reported that anthracyclines, which could generate reactive oxygen species (ROS), could induce the urokinase-type plasminogen activator (uPA) gene expression in human RC-K8 malignant lymphoma cells and in H69 small cell lung cancer (SCLC) cells. In screening other uPA-inducible anti-cancer agents, we found that camptothecin (CPT) and its derivative, SN38, could induce uPA in RC-K8 and H69 cells. CPT and SN38, which are also used for the treatment of lymphoma and SCLC, significantly increased the uPA accumulation in the conditioned media of both cells in a dose-dependent manner. The maximum induction of uPA mRNA levels was observed 24 h after stimulation. Pretreatment with pyrrolidine dithiocarbamate (PDTC), an anti-oxidant, inhibited the CPT-induced uPA mRNA expression. Thus, CPT induces uPA through gene expression, and, therefore, CPT may influence the tumor-cell biology by up-regulating the uPA/plasmin system.</p>
キーワード CPT SN38 uPA RC-K8 H69
Amo Type Article
発行日 2002-10
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 223
終了ページ 227
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12530505
Web of Science KeyUT 000178668100002
著者 柴倉 美砂子|
発行日 2003-03-25
資料タイプ 学位論文
著者 Yamaoka, Kiyonori| Mitsunobu, Fumihiro| Kojima, Shuji| Shibakura, Misako| Kataoka, Takahiro| Hanamoto, Katsumi| Tanizaki, Yoshiro|
発行日 2005-04-01
出版物タイトル Journal of Radiation Research
資料タイプ 学術雑誌論文
著者 深井 喜代子| 勝田 稔三| 近藤 麻理| 柴倉 美砂子| 浅利 正二|
発行日 2006-03-31
出版物タイトル 岡山大学医学部保健学科紀要
資料タイプ その他