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ID 49112
フルテキストURL
著者
Soga, Yoshihiko Okayama Univ
Maeda, Yoshinobu Okayama Univ
Ishimaru, Fumihiko Okayama Univ
Tanimoto, Mitsune Okayama Univ
Maeda, Hiroshi Okayama Univ
Nishimura, Fusanori Okayama Univ
Takashiba, Shogo Okayama Univ
抄録
Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. The changes in detection frequencies of CoNS and alpha-streptococci from before to 3 weeks after HCT were significant (P < 0.05, chi (2) test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P < 0.05, chi (2) test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.
キーワード
Bacterial substitution
Oral mucosa
Hematopoietic cell transplantation
Coagulase-negative Staphylococcus
Bacteremia
発行日
2011-07
出版物タイトル
Supportive Care in Cancer
19巻
7号
開始ページ
995
終了ページ
1000
ISSN
0941-4355
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/ 10.1007/s00520-010-0923-9
言語
English
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT