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ID 31114
JaLCDOI
フルテキストURL
著者
Nishioka, Keiko Hiroshima City Hospital
Saito, Chisato Okayama City Hospital
Nagano, Toshiaki Okayama Univeristy
Okano, Mitsuhiro Okayama University
Nakagawa, Fumio Okayama University
Nishioka, Satoko Okayama University
Masuda, Yu Okayama University
抄録

To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P < 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.

キーワード
mite allergen
skin test
nasal provoration test
allergen rhinitis
Amo Type
Article
発行日
1994-10
出版物タイトル
Acta Medica Okayama
48巻
5号
出版者
Okayama University Medical School
開始ページ
279
終了ページ
282
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT