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ID 48267
JaLCDOI
フルテキストURL
著者
Masuyama, Hisashi Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
Nobumoto, Etsuko Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
Segawa, Tomonori Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
Hiramatsu, Yuji Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine
抄録
Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity, diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.
キーワード
adipocytokine
angiogenic factor
diet therapy
obesity
preeclampsia
Amo Type
Case Report
発行日
2012-04
出版物タイトル
Acta Medica Okayama
66巻
2号
出版者
Okayama University Medical School
開始ページ
171
終了ページ
175
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
Submission Path
amo/vol66/iss2/10
PubMed ID
Web of Sience KeyUT