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ID 30979
JaLCDOI
フルテキストURL
著者
Imatoh, Takuya Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
Miyazaki, Motonobu Department of Health and Welfare, Saitama City Government
Momose, Yoshito Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
Uryu, Yoko Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
Tanihara, Shinichi Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
Une, Hiroshi Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University
Doi, Hiroyuki Department of Hygiene and Preventive Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
抄録

Leptin is a hormone which is predominantly secreted by adipose tissue. Recent studies have shown that leptin increases arterial blood pressure. Although data from available animal studies clearly indicate an association between leptin and hypertension, results of human studies have been less definitive. We conducted a case-control study to examine the association between serum leptin levels and hypertension in 111 hypertensive subjects and 222 male controls, using conditional logistic regression analyses. Mean serum leptin levels were found to be marginally higher in the case subjects than in the control subjects (3.3 ng/ml versus 3.0 ng/ml), however, conditional logistic regression analysis revealed that subjects in the highest quartile had a significantly increased risk of hypertension compared with those in the lowest quartile, even after adjusting for drinking status and diabetes mellitus (adjusted OR, 2.11;95% CI, 1.01-4.39). Our findings suggest that leptin plays an important role in the development of hypertension.

キーワード
epidemiological study
hyperleptinemia
hypertension
leptin
Amo Type
Original Article
発行日
2008-06
出版物タイトル
Acta Medica Okayama
62巻
3号
出版者
Okayama University Medical School
開始ページ
169
終了ページ
174
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT