著者 曽我 賢彦| Maeda, Yoshinobu| Tanimoto, Mitsune| Ebinuma, Takayuki| Maeda, Hiroshi| Takashiba, Shogo|
発行日 2013-02
出版物タイトル Supportive Care in Cancer
21巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/54603
フルテキストURL 70_5_409.pdf
著者 Maeda, Yoshinobu| Nishimori, Hisakazu| Inamoto, Yoshihiro| Nakamae, Hirohisa| Sawa, Masashi| Mori, Yasuo| Ohashi, Kazuteru| Fujiwara, Shin-ichiro| Tanimoto, Mitsune|
抄録 Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD.
キーワード Am80 tamibarotene retinoid chronic GVHD steroid-refractory GVHD
Amo Type Clinical Study Protocols
発行日 2016-10
出版物タイトル Acta Medica Okayama
70巻
5号
出版者 Okayama University Medical School
開始ページ 409
終了ページ 412
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 27777437
Web of Sience KeyUT 000388098700014
Sort Key 10
タイトル(別表記) An investigator initiated phase II clinical trial of tamibarotene (AM80G) for chronic graft-versus-host disease
フルテキストURL 127_133.pdf
著者 西森 久和| 前田 嘉信|
キーワード 臨床研究中核病院 慢性GVHD タミバロテン 同種造血幹細胞移植 Th17
備考 特集(Feature Articles)
出版物タイトル 岡山医学会雑誌
発行日 2015-08-03
127巻
2号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 133
終了ページ 137
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL isVersionOf https://doi.org/10.4044/joma.127.133
言語 Japanese
著作権者 Copyright (c) 2015 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.127.133
NAID 文ID(NAID) 130005096255
Eprints Journal Name joma
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