このエントリーをはてなブックマークに追加
ID 53635
フルテキストURL
著者
海老沼 孝至 岡山大学病院
曽我 賢彦 岡山大学病院
Sato, Takamaro Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsunaga, Kazuyuki Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kudo, Chieko Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maeda, Hiroshi Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
前田 嘉信 Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
谷本 光音 Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
髙柴 正悟 Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
[Purpose] We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT. [Methods] Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 ± 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day −7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 ± 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa. [Results] Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days −7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days −7 to −1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA). [Conclusions] mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported.
キーワード
Hematopoietic cell transplantation
Oral mucosa
Bacteria
mecA
Antibiotic-resistant
備考
The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-014-2151-1
発行日
2014-06
出版物タイトル
Supportive Care in Cancer
22巻
6号
出版者
Springer Berlin Heidelberg
開始ページ
1679
終了ページ
1683
ISSN
0941-4355
NCID
AA10996793
資料タイプ
学術雑誌論文
オフィシャル URL
http://link.springer.com/journal/520
言語
English
著作権者
Springer-Verlag Berlin Heidelberg
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT