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ID 52813
フルテキストURL
著者
Sonoi, Norihiro Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
Soga, Yoshihiko Okayama Univ Hosp, Cent Clin Dept, Div Hosp Dent
Maeda, Hiroshi Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
Ichimura, Koichi Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci
Yoshino, Tadashi Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci
Aoyama, Kazutoshi Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Fujii, Nobuharu Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Maeda, Yoshinobu Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Tanimoto, Mitsune Okayama Univ, Dept Hematol Oncol & Resp Med, Grad Sch Med Dent & Pharmaceut Sci
Logan, Richard Univ Adelaide, Fac Hlth Sci, Sch Dent
Raber-Durlacher, Judith Acad Ctr Dent Amsterdam, Dept Periodontol
Takashiba, Shogo Okayama Univ, Dept Pathophysiol Periodontal Sci, Grad Sch Med Dent & Pharmaceut Sci
抄録
Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.
キーワード
Gingival enlargement
Acute myelomonocytic leukemia
Pathogenesis
Histology
Immunohistochemistry
備考
The final publication is available at link.springer.com
発行日
2012-07
出版物タイトル
Odontology
100巻
2号
開始ページ
254
終了ページ
257
ISSN
1618-1247
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© The Society of The Nippon Dental University 2011
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT