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ID 52803
フルテキストURL
著者
Omote, Yoshio Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Deguchi, Kentaro Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Tian, FengFeng Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Kawai, Hiromi Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Kurata, Tomoko Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Yamashita, Toru Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci ORCID Kaken ID
Ohta, Yasuyuki Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci
Abe, Koji Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci Kaken ID researchmap
抄録
Background and Purpose-Cerebral infarction is a major cause of death or decreasing activities of daily living. This study aimed to investigate the efficacy of commonly used antiplatelet drugs on stroke and motor and cognitive functions in relation to oxidative stress markers and insulin-like growth factor 1 receptor (IGF-1R). Methods-Stroke-prone spontaneously hypertensive rats were treated with vehicle, aspirin, clopidogrel, and cilostazol from 8 to 10 weeks of age. Physiological parameters, regional cerebral blood flow, and serum lipids were examined. Motor and cognitive functions were evaluated weekly by the Rotorod and water maze task. Spontaneous infarct volume, oxidative stress markers for lipid, protein, and DNA at the ischemic boundary zone of spontaneous infarction, and the IGF-1R-positive cell ratio in the hippocampus were immunohistochemically examined in brain sections. IGF-1R beta expression in the hippocampus was assessed by Western blotting. Results-The antiplatelet drugs, cilostazol and clopidogrel, reduced the spontaneous infarct volume more than aspirin. Only cilostazol improved motor and cognitive functions with a significant increase (P<0.05) in the memory-related IGF-1R-positive ratio and IGF-1R beta expression in the hippocampus. Cilostazol reduced the 4 oxidative stress markers in affected neurons in stroke-prone spontaneously hypertensive rats regardless of blood pressure, regional cerebral blood flow, or serum lipid levels. Conclusions-The present results suggest that a possible pleiotropic effect of cilostazol resulted in the reduction of spontaneous infarct volume and preservation of motor and spatial cognitive functions. The increase of IGF-1R-positive cells in the hippocampal CA1 region could partly explain the preservation of spatial cognitive function in stroke-prone spontaneously hypertensive rats.
キーワード
cerebral infarction
cilostazol
IGF-1R
oxidative stress
SHR-SP
発行日
2012-06
出版物タイトル
Stroke
43巻
6号
開始ページ
1639
終了ページ
1646
ISSN
0039-2499
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52527
言語
English
著作権者
© 2012 American Heart Association, Inc. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Science KeyUT