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ID 52858
フルテキストURL
著者
Iwatani, Kayoko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Takata, Katsuyoshi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sato, Yasuharu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Miyata-Takata, Tomoko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Iwaki, Noriko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Cui, Wei Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sawada-Kitamura, Seiko Kanazawa Univ Hosp, Div Pathol
Sonobe, Hiroshi Chugoku Cent Hosp, Div Pathol
Tamura, Maiko Hiroshima City Hosp, Div Pathol
Saito, Katsuhiko Toyama City Hosp, Dept Pathol
Miyatani, Katsuya Mitoyo Gen Hosp, Div Pathol
Yamasaki, Rie Natl Hosp Org Iwakuni, Ctr Clin, Div Pathol
Yamadori, Ichiro Natl Hosp Org Okayama, Med Ctr, Div Pathol
Fujii, Nobuharu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Terasaki, Yasushi Toyama City Hosp, Div Hematol
Maeda, Yoshinobu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Tanimoto, Mitsune Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Nakamura, Naoya Tokai Univ, Inst Med Sci, Dept Pathol
Yoshino, Tadashi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
抄録
Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.
キーワード
Low-grade B cell lymphoma
Bone marrow
LGBCL-NOS
MYD88
発行日
2014-07
出版物タイトル
Human Pathology
45巻
7号
開始ページ
1379
終了ページ
1387
ISSN
0046-8177
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/52829
言語
English
OAI-PMH Set
岡山大学
著作権者
(C) 2014 Elsevier Inc. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT