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ID 52032
フルテキストURL
著者
Hayashi, Eiko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Takata, Katsuyoshi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Sato, Yasuharu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Tashiro, Yukie Imakiire Gen Hosp, Dept Pathol
Tachiyama, Yoshiro Hiroshima Nishi Med Ctr, Div Pathol
Sawada-Kitamura, Seiko Kanazawa Univ Hosp, Div Pathol
Hiramatsu, Yasushi Himeji Red Cross Hosp, Dept Hematol & Oncol
Sugiguchi, Shun Tonami Gen Hosp, Dept Pathol
Nose, Soichiro Okayama Saiseikai Gen Hosp, Dept Pathol
Hirokawa, Mitsuyoshi Kuma Hosp, Dept Diagnost Pathol
Ando, Midori Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Abd Mader, Lamia Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
Maeda, Yoshinobu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Tanimoto, Mitsune Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol & Oncol
Yoshino, Tadashi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol
抄録
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) consists of a heterogeneous group of lymphomas. Patients. generally show an aggressive clinical course and very poor outcome. Although the 2008 World Health Organization classification of PTCL-NOS includes 3 variants, low-grade lymphoma is not Included. Of 277 PTCL-NOS cases recorded in our consultation files, we examined the clinicopathologic characteristics of 10 patients with T-cell lymphomas composed of small-sized cells with slight nuclear atypia. Eight patients showed extranodal involvement (5 patients, spleen; 3 patients, thyroid), and 5 patients were at clinical stage I or II. Histologically, all samples presented diffuse infiltrate of small lymphoid cells, with few mitotic figures. Immunohistologically, all samples were positive for CD3, and CD:20 Was detected in 5 samples. All samples showed a low Ki-67 labeling index (mean, 1.05%), and 7 samples were positive for central memory T-cell markers. Clonal T-cell receptor gamma chain and/or alpha-beta chain gene rearrangements were detected in all 10 patients. Five patients received chemotherapy, whereas for 3 patients, treatment consisted only of observation following surgical resection of the spleen or thyroid. Nine patients were alive at a median follow-up time of 19.5 months, whereas 1 patient died of an unrelated disease. The present study strongly indicates that T-cell lymphoma with small-sized lymphoma cells and a low Ki-67 labeling index is a distinct variant. Recognition of this novel lymphoma subtype, which should not be defined merely as PTCL-NOS, should be seriously considered.
キーワード
Indolent PTCL
CD20
Ki-67
Memory T cell
Good prognosis
発行日
2013-09
出版物タイトル
Human Pathology
44巻
9号
開始ページ
1927
終了ページ
1936
ISSN
0046-8177
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1016/j.humpath.2013.03.002
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51963
言語
English
OAI-PMH Set
岡山大学
著作権者
(C) 2013 Published by Elsevier Inc. All rights reserved.
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT