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ID 54815
JaLCDOI
フルテキストURL
Thumnail 70_6_503.pdf 2.58 MB
著者
Kanazawa, Yui Department of aPediatrics, Okayama University Hospital
Yamashita, Yuka Clinical Research Center, Nagoya Medical Center
Fujiwara, Mitsuhiro Department of Pediatrics, Kurashiki Central Hospital
Muraoka, Michiko Department of aPediatrics, Okayama University Hospital
Washio, Kana Department of aPediatrics, Okayama University Hospital
Kanamitsu, Kiichiro Department of aPediatrics, Okayama University Hospital
Ishida, Hisashi Department of aPediatrics, Okayama University Hospital
Nakano, Takae Department of aPediatrics, Okayama University Hospital
Yamada, Miho Clinical Research Center, Nagoya Medical Center
Horibe, Keizo Clinical Research Center, Nagoya Medical Center
Tanaka, Takehiro Department of Pathology, Okayama University Hospital Kaken ID
Yoshino, Tadashi Department of Pathology, Okayama University Hospital Kaken ID publons researchmap
Shimada, Akira Department of aPediatrics, Okayama University Hospital ORCID Kaken ID researchmap
抄録
Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample.
キーワード
ALCL
NPM-ALK fusion
lymphoma
Amo Type
Case Report
発行日
2016-12
出版物タイトル
Acta Medica Okayama
70巻
6号
出版者
Okayama University Medical School
開始ページ
503
終了ページ
506
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID