JaLCDOI 10.18926/AMO/32089
フルテキストURL fulltext.pdf
著者 Iwatsuki, Keiji| Yamamoto, Takenobu| Tsuji, Kazuhide| Suzuki, Daisuke| Fujii, Kazuyasu| Matsuura, Hironori| Oono, Takashi|
抄録 <p>Epstein-Barr virus (EBV), or human herpesvirus 4 (HHV-4), infects the vast majority of adults worldwide, and establishes both nonproductive (latent) and productive (lytic) infections. Host immune responses directed against both the lytic and latent cycle-associated EBV antigens induce a diversity of clinical symptoms in patients with chronic active EBV infections who usually contain an oligoclonal pool of EBV-infected lymphocyte subsets in their blood. Episomal EBV genes in the latent infection utilize an array of evasion strategies from host immune responses: the minimized expression of EBV antigens targeted by host cytotoxic T lymphocytes (CTLs), the down-regulation of cell adhesion molecule expression, and the release of virokines to inhibit the host CTLs. The oncogenic role of latent EBV infection is not yet fully understood, but latent membrane proteins (LMPs) expressed during the latency cycle have essential biological properties leading to cellular gene expression and immortalization, and EBV-encoded gene products such as viral interleukin-10 (vIL-10) and bcl-2 homologue function to survive the EBV-infected cells. The subsequent oncogenic DNA damage may lead to the development of neoplasms. EBV-associated NK/T cell lymphoproliferative disorders are prevalent in Asia, but quite rare in Western countries. The genetic immunological background, therefore, is closely linked to the development of EBV-associated neoplasms.</p>
キーワード latent infection hydroa vacciniforme mosquito allergy chronic active EB virus infection hemophagocytic syndrome
Amo Type Article
発行日 2004-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 169
終了ページ 180
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 15551754
Web of Science KeyUT 000223559700001
著者 Kamiya, K| Aoyama, Y| Shirafuji, Y| Hamada, T| Morizane, S| Fujii, K| Hisata, K| Iwatsuki, K|
発行日 2012-08
出版物タイトル British Journal of Dermatology
資料タイプ 学術雑誌論文
著者 藤井 一恭|
発行日 2005-03-25
資料タイプ 学位論文