JaLCDOI 10.18926/AMO/55433
フルテキストURL 71_5_363.pdf
著者 Yumoto, Tetsuya| Kosaki, Yoshinori| Yamakawa, Yasuaki| Iida, Atsuyoshi| Yamamoto, Hirotsugu| Yamada, Taihei| Tsukahara, Kohei| Naito, Hiromichi| Osako, Takaaki| Nakao, Atsunori|
抄録 Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock. Chest/pelvic X-ray in conjunction with ultrasonography have been established classically as initial diagnostic imaging modalities to identify the major sources of internal bleeding including intra-thoracic, intra-abdominal, or retroperitoneal hemorrhage related to pelvic fracture. Massive soft tissue injury, regardless of whether isolated or associated with multiple injuries, occasionally causes extensive hemorrhage and acute traumatic coagulopathy. Specific types of injuries, including soft tissue injury or retroperitoneal hemorrhage unrelated to pelvic fracture, can potentially be overlooked or be considered “occult” causes of bleeding because classical diagnostic imaging often cannot exclude such injuries. The purpose of this narrative review article is to describe “occult” or unusual sources of bleeding associated with blunt trauma.
キーワード soft tissue injury subcutaneous hematoma non-cavitary hemorrhage retroperitoneal hemorrhage hemorrhagic shock
Amo Type Review
発行日 2017-10
出版物タイトル Acta Medica Okayama
71巻
5号
出版者 Okayama University Medical School
開始ページ 363
終了ページ 368
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol71/iss5/1
PubMed ID 29042693
JaLCDOI 10.18926/AMO/54987
フルテキストURL 71_2_179.pdf
著者 Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao|
抄録 Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management.
キーワード cerebral perfusion encephalopathy child intracranial pressure neurological intensive care
Amo Type Short Communication
発行日 2017-04
出版物タイトル Acta Medica Okayama
71巻
2号
出版者 Okayama University Medical School
開始ページ 179
終了ページ 180
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol71/iss2/12
PubMed ID 28420900
タイトル(別表記) Does hydrogen-rich water really work?
著者 中尾 篤典|
キーワード 水素水 抗酸化作用 抗炎症作用 臨床応用 疑似科学
備考 総説(Review)
出版物タイトル 岡山医学会雑誌
発行日 2017-04-03
129巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 9
終了ページ 15
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
言語 Japanese
著作権者 Copyright (c) 2017 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.129.9
Sort Key 3
Eprints Journal Name joma
参考文献 1 ) Iida A, Nosaka N, Yumoto T, Knaup E, Naito H, Nishiyama C, Yamakawa Y, Tsukahara K, Terado M, Sato K, Ugawa T, Nakao A : The clinical application of hydrogen as a medical treatment. Acta Med Okayama (2016) 70, 331-337. 2 ) Huang CS, Kawamura T, Toyoda Y, Nakao A : Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res ( 2010) 44, 971-982. 3 ) Nakao A, Ogino Y, Tahara K, Uchida H, Kobayashi E : Orthotopic intestinal transplantation using the cuff method in rats : A histopathological evaluation of the anastomosis. Microsurgery ( 2001) 21, 12-15. 4 ) Nakao A, Tahara K, Inoue S, Tanaka N, Kobayashi E : Experimental models of small intestinal transplantation in rats : Orthotopic versus heterotopic model. Acta Med Okayama ( 2002) 56, 69-74. 5 ) Nakao A, Nalesnik MA, Ishikawa T, Azhipa O, Demetris AJ, Murase N : Chimerism and tolerance in rat recipients of intestinal allografts from als-treated donors with and without adjunct naive-donor-strain bone-marrow cells. Transplantation ( 2003) 75, 1575-1581. 6 ) Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM : Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med ( 2000) 6, 422-428. 7 ) Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, et al. : Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med ( 2003) 9, 183-190. 8 ) Nakao A, Kimizuka K, Stolz DB, Neto JS, Kaizu T, Choi AM, Uchiyama T, Zuckerbraun BS, Nalesnik MA, Otterbein LE, Murase N : Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. Am J Pathol ( 2003) 163, 1587-1598. 9 ) Nakao A, Kimizuka K, Stolz DB, Neto JS, Kaizu T, Choi AM, Uchiyama T, Zuckerbraun BS, Bauer AJ, Nalesnik MA, Otterbein LE, Geller DA, et al. : Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts. Surgery ( 2003) 134, 285-292. 10) Nakao A, Moore BA, Murase N, Liu F, Zuckerbraun BS, Bach FH, Choi AM, Nalesnik MA, Otterbein LE, Bauer AJ : Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility. Gut (2003) 52, 1278-1285. 11) Nakao A, Sugimoto R, Billiar TR, McCurry KR : Therapeutic antioxidant medical gas. J Clin Biochem Nutr ( 2009) 44, 1-13. 12) Nakao A, Choi AM, Murase N : Protective effect of carbon monoxide in transplantation. J Cell Mol Med (2006) 10, 650-671. 13) Nakao A, Yamada T, Kohama K, Yoshie N, Fujisaki N, Kotani J : Application of carbon monoxide for treatment of acute kidney injury. Acute Medicine and Surgery ( 2014) 1, 127-134. 14) Moore BA, Overhaus M, Whitcomb J, Ifedigbo E, Choi AM, Otterbein LE, Bauer AJ : Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med ( 2005) 33, 1317-1326. 15) Mayr FB, Spiel A, Leitner J, Marsik C, Germann P, Ullrich R, Wagner O, Jilma B : Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med ( 2005) 171, 354-360. 16) Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S : Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med (2007) 13, 688-694. 17) Kawamura T, Huang CS, Tochigi N, Lee S, Shigemura N, Billiar TR, Okumura M, Nakao A, Toyoda Y : Inhaled hydrogen gas therapy for prevention of lung transplantinduced ischemia/reperfusion injury in rats. Transplantation ( 2010) 90, 1344-1351. 18) Sugimoto R, Nakao A, Nagahiro I, Kohmoto J, Sugimoto S, Okazaki M, Yamane M, Inokawa H, Oto T, Tahara K, Zhan J, Sano Y, et al. : Experimental orthotopic lung transplantation model in rats with cold storage. Surg Today ( 2009) 39, 641-645. 19) Kawamura T, Huang CS, Peng X, Masutani K, Shigemura N, Billiar TR, Okumura M, Toyoda Y, Nakao A : The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery ( 2011) 150, 240-249. 20) Tanaka Y, Shigemura N, Kawamura T, Noda K, Isse K, Stolz DB, Billiar TR, Toyoda Y, Bermudez CA, Lyons-Weiler J, Nakao A : Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun ( 2012) 425, 873-879. 21) Huang CS, Kawamura T, Lee S, Tochigi N, Shigemura N, Buchholz BM, Kloke JD, Billiar TR, Toyoda Y, Nakao A : Hydrogen inhalation ameliorates ventilator-induced lung injury. Crit Care ( 2010) 14, R234. 22) Ohta S : Molecular hydrogen as a preventive and therapeutic medical gas : Initiation, development and potential of hydrogen medicine. Pharmacol Ther ( 2014) 144, 1-11. 23) Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, et al. : Hydrogen gas reduces hyperoxic lung injury via the nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol ( 2013) 304, L646-656. 24) Strocchi A, Levitt MD : Maintaining intestinal h2 balance : Credit the colonic bacteria. Gastroenterology ( 1992) 102, 1424-1426. 25) NASA : Safety standard for hydrogen and hydrogen systems. National aeronautics and space administration, Washington, DC ( 2005) . 26) Noda K, Tanaka Y, Shigemura N, Kawamura T, Wang Y, Masutani K, Sun X, Toyoda Y, Bermudez CA, Nakao A : Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int ( 2012) 25, 1213-1222. 27) Sun Q, Kawamura T, Masutani K, Peng X, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A : Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res ( 2012) 94, 144-153. 28) Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A : Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int (2010) 77, 101-109. 29) Kajiya M, Silva MJ, Sato K, Ouhara K, Kawai T : Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun (2009) 386, 11-15. 30) Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, et al. : Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of parkinson's disease. PLoS One ( 2009) 4, e7247. 31) Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, et al. : Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology ( 2012) 56, 912-921. 32) Abe T, Li XK, Yazawa K, Hatayama N, Xie L, Sato B, Kakuta Y, Tsutahara K, Okumi M, Tsuda H, Kaimori JY, Isaka Y, et al. : Hydrogen-rich university of wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation ( 2012) 94, 14-21. 33) Buchholz BM, Masutani K, Kawamura T, Peng X, Toyoda Y, Billiar TR, Bauer AJ, Nakao A : Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation ( 2011) 92, 985-992. 34) Noda K, Shigemura N, Tanaka Y, Kawamura T, Hyun Lim S, Kokubo K, Billiar TR, Bermudez CA, Kobayashi H, Nakao A : A novel method of preserving cardiac grafts using a hydrogen-rich water bath. J Heart Lung Transplant (2013) 32, 241-250. 35) Okamoto A, Kohama K, Aoyama-Ishikawa M, Yamashita H, Fujisaki N, Yamada T, Yumoto T, Nosaka N, Naito H, Tsukahara K, Iida A, Sato K, et al. : Intraperitoneally administered, hydrogen-rich physiologic solution protects against postoperative ileus and is associated with reduced nitric oxide production. Surgery ( 2016) 160, 623-631. 36) Ren J, Luo Z, Tian F, Wang Q, Li K, Wang C : Hydrogenrich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg ( 2012) 72, 1555-1561. 37) Kasuyama K, Tomofuji T, Ekuni D, Tamaki N, Azuma T, Irie K, Endo Y, Morita M : Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol ( 2011) 38, 1085-1090. 38) Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Irie K, Azuma T, Tamaki N, Mizutani S, Kojima A, Morita M : Hydrogenrich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol (2012) 57, 1615-1622. 39) Oharazawa H, Igarashi T, Yokota T, Fujii H, Suzuki H, Machide M, Takahashi H, Ohta S, Ohsawa I : Protection of the retina by rapid diffusion of hydrogen : Administration of hydrogen-loaded eye drops in retinal ischemiareperfusion injury. Invest Ophthalmol Vis Sci ( 2010) 51, 487-492. 40) Yokota T, Kamimura N, Igarashi T, Takahashi H, Ohta S, Oharazawa H : Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Exp Ophthalmol (2015) 43, 568-577. 41) Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S : Pilot study : Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res ( 2012) 2, 12. 42) Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N : Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr ( 2010) 46, 140-149. 43) Kang KM, Kang YN, Choi IB, Gu Y, Kawamura T, Toyoda Y, Nakao A : Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res ( 2011) 1, 11. 44) Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, Naritomi Y, Hara H, Nagao T : Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis : An open-label pilot study. Med Gas Res ( 2012) 2, 27. 45) Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S : A novel bioactive haemodialysis system using dissolved dihydrogen (h2) produces by water electrolysis : A clinical trial. Nephrol Dial Transplant (2010) 25, 3026-3033. 46) Matsumoto S, Ueda T, Kakizaki H : Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology (2013) 81, 226-230.
JaLCDOI 10.18926/AMO/54590
フルテキストURL 70_5_331.pdf
著者 Iida, Atsuyoshi| Nosaka, Nobuyuki| Yumoto, Tetsuya| Knaup, Emily| Naito, Hiromichi| Nishiyama, Chihiro| Yamakawa, Yasuaki| Tsukahara, Kohei| Terado, Michihisa| Sato, Keiji| Ugawa, Toyomu| Nakao, Atsunori|
抄録 In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogenʼs effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.
キーワード hydrogen antioxidant effect medical gas gaseous signaling molecule clinical tests
Amo Type Review
発行日 2016-10
出版物タイトル Acta Medica Okayama
70巻
5号
出版者 Okayama University Medical School
開始ページ 331
終了ページ 337
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Submission Path amo/vol70/iss5/1
PubMed ID 27777424
Web of Sience KeyUT 000388098700001