このエントリーをはてなブックマークに追加
ID 61256
フルテキストURL
fulltext.pdf 1.49 MB
著者
Morita, Hiroshi Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Asada, Saori T. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Miyamoto, Masakazu Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Morimoto, Yoshimasa Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Kimura, Tomonari Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Mizuno, Tomofumi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Nakagawa, Koji Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry
Watanabe, Atsuyuki Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry Kaken ID
Nishii, Nobuhiro Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons
Ito, Hiroshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry Kaken ID
抄録
Background
Sinus tachycardia during exercise attenuates ST‐segment elevation in patients with Brugada syndrome, whereas ST‐segment augmentation after an exercise test is a high‐risk sign. Some patients have premature ventricular contractions (PVCs) related to exercise, but the significance of exercise‐related PVCs in patients with Brugada syndrome is still unknown. The objective of this study was to determine the significance of exercise‐related PVCs for predicting occurrence of ventricular fibrillation (VF) in patients with Brugada syndrome.
Methods and Results
The subjects were 307 patients with Brugada syndrome who performed a treadmill exercise test. We evaluated the occurrence of PVCs at rest, during exercise and at the peak of exercise, and during recovery after exercise (0–5 minutes). We followed the patients for 92±68 months and evaluated the occurrence of VF. PVCs occurred in 82 patients (27%) at the time of treadmill exercise test: PVCs appeared at rest in 14 patients (4%), during exercise in 60 patients (20%), immediately after exercise (0–1.5 minutes) in 28 patients (9%), early after exercise (1.5–3 minutes) in 18 patients (6%), and late after exercise (3–5 minutes) in 12 patients (4%). Thirty patients experienced VF during follow‐up. Multivariable analysis including symptoms, spontaneous type 1 ECG, and PVCs in the early recovery phase showed that these factors were independently associated with VF events during follow‐up.
Conclusions
PVCs early after an exercise test are associated with future occurrence of VF events. Rebound of vagal nerve activity at the early recovery phase would promote ST‐segment augmentation and PVCs in high‐risk patients with Brugada syndrome.
キーワード
Brugada syndrome
exercise test
premature ventricular contractions
sudden death
ventricular fibrillation
発行日
2020-11-23
出版物タイトル
Journal of the American Heart Association
9巻
23号
出版者
Wiley
開始ページ
e016907
ISSN
2047-9980
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2020 The Authors.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1161/JAHA.120.016907
ライセンス
https://creativecommons.org/licenses/by-nc-nd/4.0/
助成機関名
日本学術振興会
助成番号
15K09082