フルテキストURL PhysRevE_91_016302.pdf
著者 Yagasaki, Takuma| Matsumoto, Masakazu| Tanaka, Hideki|
抄録 Two different scenarios have been proposed on the phase separation occurring in the deeply supercooled liquid water. We discuss what we can derive from our simulation results for the two scenarios and propose a way for future investigation. We also demonstrate that the phase separation in the supercooled liquid water looks like the separation of liquid water and vapor just below the conventional critical point.
発行日 2015-01-23
出版物タイトル Physical review. E, Statistical, nonlinear, and soft matter physics
91巻
1号
出版者 American Physical Society
開始ページ 016302
ISSN 1539-3755
NCID AA11558033
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 25679745
DOI 10.1103/PhysRevE.91.016302
Web of Sience KeyUT 000349487700008
関連URL https://doi.org/10.1103/PhysRevE.91.016302
フルテキストURL Jpn_J_Nurs_Sci_12_4_276.pdf Jpn_J_Nurs_Sci_12_4_276_fig.pdf
著者 Toki, Kazue| Yamai, Terumi| Fukai, Kiyoko|
抄録 AIM: The objectives of this study were to examine skin temperature changes on the unaffected and affected sides as well as changes in perceived temperature and comfort during a footbath in patients who had had a stroke with consequent sensory impairment. METHODS: The study used a quasi-experimental design in which the results of intervention for patients who had had a stroke and healthy adults were compared. The subjects were 20 patients who had had a stroke with consequent sensory impairment and 20 healthy adults. RESULTS: Before the footbath, the skin temperature of the dorsum of the foot on the affected side of the patient who had had a stroke was lower than that of the foot on the unaffected side. Five minutes after the start of the footbath, however, the relationship reversed, with the skin temperature on the affected side increasing in parallel with the water temperature. After the footbath, the dorsum skin temperature on the affected side was again lower than that on the unaffected side. In healthy adults, a difference was found in dorsum skin temperature between the left and right feet. In contrast with patients who had had a stroke, no reversal of the sides was found with the lower and higher temperature. CONCLUSION: Unlike in the healthy adults, the skin temperature of the patients who had had a stroke with consequent sensory impairment was susceptible to changes in the external environment. However, no significant changes in the physiological indices were seen, while perceived temperature and comfort remained at high levels after the footbath.
キーワード footbath patient who had a stroke sensory impairment skin temperature
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2015-12-10
出版物タイトル Japan Journal of Nursing Science
12巻
4号
出版者 Japan Academy of Nursing Science
開始ページ 276
終了ページ 286
ISSN 1742-7932
NCID AA12141366
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25496027
DOI 10.1111/jjns.12066
Web of Sience KeyUT 000362529100002
関連URL https://doi.org/10.1111/jjns.12066
フルテキストURL plosone_7_11_e50082.PDF
著者 Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko|
抄録 Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide transporter-1 and -2, ferrochelatase and ATP-binding cassette transporter G2 (ABCG2), in several tumor cell lines. Among these proteins, only ABCG2 correlated negatively with ALA-mediated PpIX accumulation. Both a subcellular fractionation study and confocal laser microscopic analysis revealed that ABCG2 was distributed not only in the plasma membrane but also intracellular organelles, including mitochondria. In addition, mitochondrial ABCG2 regulated the content of ALA-mediated PpIX in mitochondria, and Ko143, a specific inhibitor of ABCG2, enhanced mitochondrial PpIX accumulation. To clarify the possible roles of mitochondrial ABCG2, we characterized stably transfected-HEK (ST-HEK) cells overexpressing ABCG2. In these ST-HEK cells, functionally active ABCG2 was detected in mitochondria, and treatment with Ko143 increased ALA-mediated mitochondrial PpIX accumulation. Moreover, the mitochondria isolated from ST-HEK cells exported doxorubicin probably through ABCG2, because the export of doxorubicin was inhibited by Ko143. The susceptibility of ABCG2 distributed in mitochondria to proteinase K, endoglycosidase H and peptide-N-glycosidase F suggested that ABCG2 in mitochondrial fraction is modified by N-glycans and trafficked through the endoplasmic reticulum and Golgi apparatus and finally localizes within the mitochondria. Thus, it was found that ABCG2 distributed in mitochondria is a functional transporter and that the mitochondrial ABCG2 regulates ALA-mediated PpIX level through PpIX export from mitochondria to the cytosol.
発行日 2012-11-26
出版物タイトル PLoS ONE
7巻
11号
出版者 Public Library of Science
開始ページ e50082
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 23189181
DOI 10.1371/journal.pone.0050082
Web of Sience KeyUT 000311929800058
関連URL https://doi.org/10.1371/journal.pone.0050082
フルテキストURL IFAC_49_8_7.pdf
著者 Imai, Jun| Noso, Katsuyuki| Takahashi, Akiko| Funabiki, Shigeyuki|
抄録 For linear distributed parameter systems with a finite number of boundary inputs, we propose a framework to implement the method of weighted residuals using candidate trial functions without boundary homogenization. Proposed scheme utilizes inner product matrix, or Grammian, of the trial functions to separate appropriate homogenized basis functions and the other trial functions matching inhomogeneous boundary conditions. The finite-dimensional approximate model by using the proposed scheme is represented in descriptor form and it is proved to be straightforwardly transformed into state space form. Feasibility of the method is illustrated by a brief controller design example using the approximate model of a heat conduction rod with Dirichlet boundary input.
キーワード Distributed parameter systems Method of weighted residuals Boundary conditions Reduced-order models
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2016-08-09
出版物タイトル IFAC-Papers OnLine
49巻
8号
出版者 Elsevier
開始ページ 7
終了ページ 12
ISSN 2405-8963
資料タイプ 学術雑誌論文
言語 Japanese
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.ifacol.2016.07.410
Web of Sience KeyUT 000381505200003
関連URL https://doi.org/10.1016/j.ifacol.2016.07.410
フルテキストURL blood_119_1_285.pdf
著者 Nishimori, Hisakazu| Maeda, Yoshinobu| Teshima, Takanori| Sugiyama, Haruko| Kobayashi, Koichiro| Yamasuji, Yoshiko| Kadohisa, Sachiyo| Uryu, Hidetaka| Takeuchi, Kengo| Tanaka, Takehiro| Yoshino, Tadashi| Iwakura, Yoichiro| Tanimoto, Mitsune|
抄録 Chronic GVHD (cGVHD) is a main cause of late death and morbidity after allogeneic hematopoietic cell transplantation, but its pathogenesis remains unclear. We investigated the roles of Th subsets in cGVHD with the use of a well-defined mouse model of cGVHD. In this model, development of cGVHD was associated with up-regulated Th1, Th2, and Th17 responses. Th1 and Th2 responses were up-regulated early after BM transplantation, followed by a subsequent up-regulation of Th17 cells. Significantly greater numbers of Th17 cells were infiltrated in the lung and liver from allogeneic recipients than those from syngeneic recipients. We then evaluated the roles of Th1 and Th17 in cGVHD with the use of IFN-γ-deficient and IL-17-deficient mice as donors. Infusion of IFN-γ(-/-) or IL-17(-/-) T cells attenuated cGVHD in the skin and salivary glands. Am80, a potent synthetic retinoid, regulated both Th1 and Th17 responses as well as TGF-β expression in the skin, resulting in an attenuation of cutaneous cGVHD. These results suggest that Th1 and Th17 contribute to the development of cGVHD and that targeting Th1 and Th17 may therefore represent a promising therapeutic strategy for preventing and treating cGVHD.
備考 This research was originally published in Blood. 2012. © the American Society of Hematology.
発行日 2012-01-05
出版物タイトル Blood
119巻
1号
開始ページ 285
終了ページ 295
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 22077062
DOI 10.1182/blood-2011-01-332478
Web of Sience KeyUT 000299012400035
関連URL https://doi.org/10.1182/blood-2011-01-332478
著者 Hashimoto, Mitsuyasu|
抄録 Using the description of the Frobenius limit of modules over the ring of invariants under an action of a finite group on a polynomial ring over a field of characteristic p>0 developed by Symonds and the author, we give a characterization of the ring of invariants with a positive dual F-signature. Combining this result and Kemper's result on depths of the ring of invariants under an action of a permutation group, we give an example of an F-rational, but non-F-regular ring of invariants under the action of a finite group.
キーワード F-rational F-regular Dual F-signature Frobenius limit
備考 This is an Accepted Manuscript of an article published by Elsevier This fulltext available in Aug 2019
発行日 2017-08-15
出版物タイトル Journal of Algebra
484巻
出版者 Elsevier
開始ページ 207
終了ページ 223
ISSN 0021-8693
NCID AA00692420
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.jalgebra.2017.04.017
Web of Sience KeyUT 000403626100010
関連URL https://doi.org/10.1016/j.jalgebra.2017.04.017
著者 Hashimoto, Mitsuyasu|
抄録 We define canonical and -canonical modules of a module-finite algebra over a Noether commutative ring and study their basic properties. Using -canonical modules, we generalize a theorem on -syzygy by Araya and Iima which generalize a well-known theorem on syzygies by Evans and Griffith. Among others, we prove a noncommutative version of Aoyama’s theorem which states that a canonical module descends with respect to a flat local homomorphism.
備考 This is an Accepted Manuscript of an article published by Cambridge University Press This fulltext availavle in Dec 2017
発行日 2017-06
出版物タイトル Nagoya Mathematical Journal
226巻
出版者 Cambridge University Press
開始ページ 165
終了ページ 203
ISSN 0027-7630
NCID AA00750899
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works.
論文のバージョン author
DOI 10.1017/nmj.2016.44
関連URL https://doi.org/10.1017/nmj.2016.44 https://arxiv.org/abs/1508.07552
著者 Hashimoto, Mitsuyasu| Symondsb, Peter|
抄録 We define the Frobenius limit of a module over a ring of prime characteristic to be the limit of the normalized Frobenius direct images in a certain Grothendieck group. When a finite group acts on a polynomial ring, we calculate this limit for all the modules over the twisted group algebra that are free over the polynomial ring; we also calculate the Frobenius limit for the restriction of these to the ring of invariants. As an application, we generalize the description of the generalized F-signature of a ring of invariants by the second author and Nakajima to the modular case.
キーワード Frobenius direct image Hilbert–Kunz multiplicity F-signature Frobenius limit
備考 This is an Accepted Manuscript of an article published by Elsevier Fulltext available in Jan 2019
発行日 2017-01-10
出版物タイトル Advances in Mathematics
305巻
出版者 Elsevier
開始ページ 144
終了ページ 164
ISSN 0001-8708
NCID AA00513055
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1016/j.aim.2016.09.020
Web of Sience KeyUT 000406169200003
関連URL https://doi.org/10.1016/j.aim.2016.09.020
著者 Hashimoto, Mitsuyasu|
抄録 We prove a version of Grothendieck’s descent theorem on an ‘enriched’ principal fiber bundle, a principal fiber bundle with an action of a larger group scheme. Using this, we prove the isomorphisms of the equivariant Picard and the class groups arising from such a principal fiber bundle.
キーワード Class group descent theory Picard group principal fiber bundle
備考 This is an Accepted Manuscript of an article published by Taylor & Francis Group. Fulltext available in Oct. 2017
発行日 2016-10-07
出版物タイトル Communications in Algebra
45巻
4号
出版者 Taylor & Francis
開始ページ 1509
終了ページ 1532
ISSN 0092-7872
NCID AA00611371
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
DOI 10.1080/00927872.2016.1178270
Web of Sience KeyUT 000389500800010
関連URL https://doi.org/10.1080/00927872.2016.1178270
著者 Nishimori, Hisakazu| Fujii, Nobuharu| Fujii, Keiko| Ikeda, Tohru| Asano, Naomi| Ogo, Hiroaki| Yamakawa, Miwa| Takagi, Naoe| Otsuka, Fumio| Ikeda, Kazuma|
抄録 Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0-17 years old (16/320, 5.0%) than in patients 18 years and older (71/3872, 1.8%). In particular, VVRs occurred more frequently in those 10-13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection.
キーワード Autologous blood donation Vasovagal reactions
備考 This is an Accepted Manuscript of an article published by Springer This Fulltext available in Jun 2018
発行日 2017-06
出版物タイトル International Journal of Hematology
105巻
6号
出版者 Elsevier Science
開始ページ 812
終了ページ 818
ISSN 0925-5710
NCID AA10797094
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28271415
DOI 10.1007/s12185-017-2204-6
Web of Sience KeyUT 000401324100014
関連URL https://doi.org/10.1007/s12185-017-2204-6
フルテキストURL s12885-017-3295-4.pdf
著者 Yokota, T.| Ogawa, T.| Takahashi, S.| Okami, K.| Fujii, T.| Tanaka, K.| Iwae, S.| Ota, I.| Ueda, T.| Monden, N.| Matsuura, K.| Kojima, H.| Ueda, S.| Sasaki, K.| Fujimoto, Y.| Hasegawa, Y.| Beppu, T.| Nishimori, Hisakazu| Hirano, S.| Naka, Y.| Matsushima, Y.| Fujii, M.| Tahara, M.|
抄録 BACKGROUND: Recent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in patients with oral cancer. This placebo-controlled randomized phase II study assessed the clinical benefit of rebamipide in reducing the incidence of severe chemoradiotherapy-induced oral mucositis in patients with head and neck cancer (HNC). METHODS: Patients aged 20-75 years with HNC who were scheduled to receive chemoradiotherapy were enrolled. Patients were randomized to receive rebamipide 2% liquid, rebamipide 4% liquid, or placebo. The primary endpoint was the incidence of grade ≥ 3 oral mucositis determined by clinical examination and assessed by central review according to the Common Terminology Criteria of Adverse Events version 3.0. Secondary endpoints were the time to onset of grade ≥ 3 oral mucositis and the incidence of functional impairment (grade ≥ 3) based on the evaluation by the Oral Mucositis Evaluation Committee. RESULTS: From April 2014 to August 2015, 97 patients with HNC were enrolled, of whom 94 received treatment. The incidence of grade ≥ 3 oral mucositis was 29% and 25% in the rebamipide 2% and 4% groups, respectively, compared with 39% in the placebo group. The proportion of patients who did not develop grade ≥ 3 oral mucositis by day 50 of treatment was 57.9% in the placebo group, whereas the proportion was 68.0% in the rebamipide 2% group and 71.3% in the rebamipide 4% group. The incidences of adverse events potentially related to the study drug were 16%, 26%, and 13% in the placebo, rebamipide 2%, and rebamipide 4% groups, respectively. There was no significant difference in treatment compliance among the groups. CONCLUSIONS: The present phase II study suggests that mouth washing with rebamipide may be effective and safe for patients with HNC receiving chemoradiotherapy, and 4% liquid is the optimal dose of rebamipide. TRIAL REGISTRATION: ClinicalTrials.gov under the identifier NCT02085460 (the date of trial registration: March 11, 2014).
キーワード Chemoradiotherapy Head and neck cancer Oral mucositis Placebo-controlled Randomized Rebamipide liquid
発行日 2017-05-05
出版物タイトル BMC cancer
17巻
1号
出版者 BioMed Central
開始ページ 314
終了ページ 322
ISSN 1471-2407
NCID AA12034763
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28476132
DOI 10.1186/s12885-017-3295-4
Web of Sience KeyUT 000401614700001
関連URL https://doi.org/10.1186/s12885-017-3295-4
フルテキストURL 17P-SO3-Sia-SR.pdf
著者 Vavricka, Christopher J.| Muto, Chiaki| Hasunuma, Tomohisa| Kimura, Yoshinobu| Araki, Michihiro| Wu, Yan| Gao, George F.| Ohrui, Hiroshi| Izumi, Minoru| Kiyota, Hiromasa|
抄録 The design, synthesis and application of N-acetylneuraminic acid-derived compounds bearing anomeric sulfo functional groups are described. These novel compounds, which we refer to as sulfo-sialic acid analogues, include 2-decarboxy-2-deoxy-2-sulfo-N-acetylneuraminic acid and its 4-deoxy-3,4-dehydrogenated pseudoglycal. While 2-decarboxy-2-deoxy-2-sulfo-N-acetylneuraminic acid contains no further modifications of the 2-deoxy-pyranose ring, it is still a more potent inhibitor of avian-origin H5N1 neuraminidase (NA) and drug-resistant His275Tyr NA as compared to the oxocarbenium ion transition state analogue 2,3-dehydro-2-deoxy-N-acetylneuraminic acid. The sulfo-sialic acid analogues described in this report are also more potent inhibitors of influenza NA (up to 40-fold) and bacterial NA (up to 8.5-fold) relative to the corresponding anomeric phosphonic acids. These results confirm that this novel anomeric sulfo modification offers great potential to improve the potency of next-generation NA inhibitors including covalent inhibitors.
キーワード Antiviral agents Drug discovery and development Glycosides
発行日 2017-08
出版物タイトル Scientific Reports
7巻
1号
出版者 Nature Publishing Group
開始ページ 8239
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28811524
DOI 10.1038/s41598-017-07836-y
Web of Sience KeyUT 000407570000116
関連URL https://doi.org/10.1038/s41598-017-07836-y
フルテキストURL olj_67_1_(106)_(95).pdf
著者 Tohnai, Kazuhiro|
備考 研究ノート(Research Note)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 106
終了ページ 95
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 German
論文のバージョン publisher
査読 有り
Sort Key 7
Eprints Journal Name olj
タイトル(別表記) A Study on Prioritizing Claims on Joint Suit upon Application for Simultaneous Trial and Decision
フルテキストURL olj_67_1_31_59.pdf
著者 濵田 陽子|
備考 論説 (Article)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 61
終了ページ 82
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 Japanese
論文のバージョン publisher
査読 有り
Sort Key 6
Eprints Journal Name olj
タイトル(別表記) Die strafrechtliche Relevanz von terminalen Sedierungsbehandlungen
フルテキストURL olj_67_1_31_59.pdf
著者 一原 亜貴子|
備考 論説 (Article)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 31
終了ページ 59
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 Japanese
論文のバージョン publisher
査読 有り
Sort Key 5
Eprints Journal Name olj
タイトル(別表記) Civil Liberties and Human Rights in the United Kingdom
フルテキストURL olj_67_1_(142)_(108).pdf
著者 木下 和朗|
備考 論説 (Article)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 142
終了ページ 108
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 Japanese
論文のバージョン publisher
査読 有り
Sort Key 4
Eprints Journal Name olj
タイトル(別表記) Licensing Parents and Liberalism
著者 大江 洋|
備考 論説 (Article)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 178
終了ページ 144
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 Japanese
論文のバージョン publisher
査読 有り
Sort Key 3
Eprints Journal Name olj
タイトル(別表記) The Birth of a Satirical Writer: Jonathan Swift’s Thought in His Early Years
フルテキストURL olj_67_1_1_29.pdf
著者 岸本 広司|
備考 論説 (Article)
出版物タイトル 岡山大學法學會雜誌
発行日 2017-08-31
67巻
1号
出版者 岡山大学法学会
出版者(別表記) The Association of Law of Okayama University
開始ページ 1
終了ページ 29
ISSN 0386-3050
NCID AN00033040
資料タイプ 学術雑誌論文
言語 Japanese
論文のバージョン publisher
査読 有り
Sort Key 2
Eprints Journal Name olj
フルテキストURL J_Pharm_Sci_130_1_24.pdf
著者 Tangsucharit, Panot| Takatori, Shingo| Zamami, Yoshito| Goda, Mitsuhiro| Pakdeechote, Poungrat| Kawasaki, Hiromu| Takayama, Fusako|
抄録 The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries. Changes in perfusion pressure to periarterial nerve stimulation and ACh were measured before and after the perfusion of Krebs solution containing muscarinic receptor antagonists. Distributions of muscarinic AChR subtypes in mesenteric arteries with an intact endothelium were studied using Western blotting. The expression level of M1 and M3 was significantly greater than that of M2. Endothelium removal significantly decreased expression levels of M2 and M3, but not M1. In perfused mesenteric vascular beds with intact endothelium and active tone, exogenous ACh (1, 10, and 100 nmol) produced concentration-dependent and long-lasting vasodilatations. In endothelium-denuded preparations, relaxation to ACh (1 nmol) disappeared, but ACh at 10 and 100 nmol caused long-lasting vasodilatations, which were markedly blocked by the treatment of pirenzepine (M1 antagonist) or 4-DAMP (M1 and M3 antagonist) plus hexamethonium (nicotinic AChR antagonist), but not methoctramine (M2 and M4 antagonist). These results suggest that muscarinic AChR subtypes, mainly M1, distribute throughout the rat mesenteric arteries, and that activation of M1 and/or M3 which may be located on CGRPergic nerves releases CGRP, causing an endothelium-independent vasodilatation.
キーワード Acetylcholine-induced vasodilatation CGRPergic nerves Muscarinic receptor subtypes Rat mesenteric arteries
発行日 2016-01
出版物タイトル Journal of Pharmacological Sciences
130巻
1号
出版者 Japanese Pharmacological Society
開始ページ 24
終了ページ 32
ISSN 1347-8613
NCID AA11806667
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 26825997
DOI 10.1016/j.jphs.2015.12.005
Web of Sience KeyUT 000369700500004
関連URL https://doi.org/10.1016/j.jphs.2015.12.005
フルテキストURL K0005304 other1.pdf
著者 Igawa, Takuro| Sato, Yasuharu| Takata, Katsuyoshi| Iwaki, Noriko| Tanaka, Takehiro| Asano, Naoko| Maeda, Yoshinobu| Orita, Yorihisa| Nakamura, Naoya| Nakamura, Shigeo| Yoshino, Tadashi|
抄録  D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma.
キーワード Cyclin D2 CD5 Diffuse large B-cell lymphoma
備考 学位審査副論文
発行日 2013-05-15
出版物タイトル Diagnostic Pathology
8巻
出版者 BioMed Central
開始ページ 81
ISSN 1746-1596
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 23675804
DOI 10.1186/1746-1596-8-81
Web of Sience KeyUT 000319266300002
関連URL https://doi.org/10.1186/1746-1596-8-81 http://ousar.lib.okayama-u.ac.jp/54287