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ID 11700
Eprint ID
11700
フルテキストURL
K003308.pdf 87.4 KB
タイトル(別表記)
ヒスタミンN-メチル基転移酵素阻害薬,アモジアキンのP. acnes-LPS誘発性肝炎におよぼす効果
著者
横山 玲 岡山大学
抄録
We examined whether treatment with amodiaquine, a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis. The subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with the decrease in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Amodiaquine partially suppressed increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver, whereas the expression of interleukin (IL)-18, interferon (IFN)-gamma and IL-12 in the liver was not changed by amodiaquine treatment. In conclusion, the present findings suggested that the elevation of endogenous histamine by amodiaquine may thus play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice.
キーワード
Amodiaquine
Propionibacterium acnes
Lipopolysaccharide
Hepatitis
備考
http://dx.doi.org/10.1016/j.ejphar.2006.11.033
発行日
2007-03-23
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3308号
学位授与年月日
2007-03-23
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17222819&dopt=Abstract
言語
Japanese
論文のバージョン
none
査読
不明