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ID 12078
Eprint ID
12078
フルテキストURL
K003365.pdf 251 KB
タイトル(別表記)
軟骨細胞におけるLRP1,CCN2受容体の機能の可能性
著者
河田 かずみ 岡山大学
抄録
Low density lipoprotein receptor (LDLR)-related protein 1 (LRP1/CD91) is one of the receptors of CCN2 that conducts endochondral ossification and cartilage repair. LRP1 is a well-known endocytic receptor, but its distribution among chondrocytes remains to be elucidated. We herein demonstrate for the first time that the distribution of LRP1 in chondrocytes except for hypertrophic chondrocytes in vivo and in vitro. Interestingly, the LRP1 levels were higher in mature chondrocytic HCS-2/8 and osteoblastic SaOS-2 than in other cells, whereas the other LDLR family members involved in ossification were detected at lower levels in HCS-2/8. It was interesting to note that in HCS-2/8, LRP1 was observed not only on the cell surface and in the cytoplasm, but also in the nucleus. Exogenously added CCN2 was incorporated into HCS-2/8, which was partially co-localized with LRP1, and targeted to the recycling endosomes and nucleus as well as the lysosomes. These findings suggest specific roles of LRP1 in cartilage biology.
キーワード
Low density lipoprotein receptor-related protein 1 (LRP1)
Cartilage
Chondrocyte differentiation
CCN2/connective tissue growth factor (CTGF)
Endocytosis
備考
http://dx.doi.org/10.1016/j.bbrc.2006.04.109
発行日
2006-03-24
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第3365号
学位授与年月日
2006-03-24
学位・専攻分野
博士(歯学)
授与大学
岡山大学
言語
Japanese
論文のバージョン
none
査読
不明