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ID 8462
Eprint ID
8462
フルテキストURL
K002848.pdf 102 KB
タイトル(別表記)
肝細胞増殖因子の遺伝子治療は心筋虚血の動物モデルにおいて心室性不整脈を抑制する
著者
湯本 晃久 岡山大学
抄録
It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia.
キーワード
ventricular arrhythmia
HGF (hepatocyte growth factor)
ischemia
HVJ (hemagglutinating
備考
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16049559&dopt=Abstract
発行日
2005-03-25
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第2848号
学位授与年月日
2005-03-25
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://escholarship.lib.okayama-u.ac.jp/cgi/viewcontent.cgi?article=1296&context=amo
言語
Japanese
論文のバージョン
none
査読
不明