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ID 32021
JaLCDOI
フルテキストURL
著者
Zamolo, Gordana Clinical Hospital Centre
Gruber, Franjo Clinical Hospital Centre
Cabrijan, Leo Clinical Hospital Centre
Micovic, Vladimir Health House
Iternicka, Zlatko Clinical Hospital Centre
Jonjic, Nives Clinical Hospital Centre
抄録

Eighty-eight cases of cutaneous melanoma (CM) were analyzed in order to elucidate the relationship between thickness, angiogenesis, and prognosis. The thickness of the tumor was measured according to the Breslow method, and the microvessels were identified by an immunohistochemical study using anti-factor VIII monoclonal antibody on specimens from 40 patients with superficial spreading melanoma (SSM), and 48 with nodular type (NM). Microvessels were counted in the area of highest density. The overall survival and disease-free period were analyzed retrospectively. The proportion of patients with thicker CMs (> 1.5 mm) increased with age in both sexes. Mean vascular count was statistically significant different only between thinner and thicker tumors in the SSM group (P < 0.05). Prognosis was correlated with the thickness of CM (P = 0.0002), mean vascular count alone (P = 0.004), mean vascular count in association with CM thickness less than 1.5 mm (P = 0.0005), and with mean vascular count in NM (P = 0.02). These findings suggest that increasing microvessel density indicates a worsening prognosis.

キーワード
cutaneous melanoma
anigiogenesis
thickness
prognosis
Amo Type
Article
発行日
2001-11
出版物タイトル
Acta Medica Okayama
55巻
5号
出版者
Okayama University Medical School
開始ページ
289
終了ページ
293
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT