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ID 52408
JaLCDOI
フルテキストURL
著者
Takeda, Akiko Department of Pediatrics, Okayama University Hospital
Shimada, Akira Department of Pediatrics, Okayama University Hospital
Hamamoto, Kazuko Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Yoshino, Syuuji Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Nagai, Tomoko Department of Pharmacology, Meijo University
Fujii, Yousuke Department of Pediatrics, Okayama University Hospital
Yamada, Mutsuko Department of Pediatrics, Okayama University Hospital
Nakamura, Yoshimi Department of Division of Medical Support,, Okayama University Hospital
Watanabe, Toshiyuki Department of Division of Medical Support,, Okayama University Hospital
Watanabe, Yuki Department of Pediatrics, Okayama University Hospital
Yamamoto, Yuko Department of Pediatrics, Okayama University Hospital
Sakakibara, Kanae Department of Laboratory Medicine, National Hospital Organization Okayama Medical Center
Oda, Megumi Department of Pediatric Hematology/Oncology, Okayama University Hospital
Morishima, Tsuneo Department of Pediatrics, Okayama University Hospital
抄録
Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of this type of AMKL can be difficult, because a subset of patients have a bone marrow (BM) blast percentage of less than 20% due to BM fibrosis. Therefore, it is possible that past studies have underestimated this type of AMKL. We present here the case of a 4-month-old female AMKL patient who was diagnosed by presence of the RBM15-MKL1 (OTT-MAL) fusion transcript by RT-PCR. In addition, we monitored RBM15-MKL1 fusion at several time points as a marker of minimal residual disease (MRD), and found that it was continuously negative after the first induction chemotherapy even by nested RT-PCR. Detection of the RBM15-MKL1 fusion transcript thus seems to be useful for accurate diagnosis of AMKL with t(1;22)(p13;q13). We recommend that the RBM15-MKL1 fusion transcript be analyzed for all suspected AMKL in infants and young children. Furthermore, monitoring of MRD using this fusion transcript would be useful in treatment of AMKL with t(1;22)(p13;q13).
キーワード
AMKL
infant
RBM15-MKL1
OTT-MAL
Amo Type
Case Report
発行日
2014-04
出版物タイトル
Acta Medica Okayama
68巻
2号
出版者
Okayama University Medical School
開始ページ
119
終了ページ
123
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT