JaLCDOI 10.18926/AMO/32423
フルテキストURL fulltext.pdf
著者 Hattori, Yukio| Moriwaki, Akiyoshi| Nishida, Nobuyoshi| Yasuhara, Hiromichi| Hori, Yasuyo|
抄録 <p>A chronic epileptic focus was induced by a microinjection of ferric chloride solution into the sensorimotor cortex of rats. Two types of somatosensory evoked potentials (SEPs) were recorded from the cortex near the injection site. In animals showing an initial positive-negative biphasic SEP, spikes appeared in electrocorticograms (ECoGs) more frequently on the side ipsilateral to the injection site than on the contralateral side, whereas in animals showing an initial negative monophasic SEP, spikes appeared more frequently on the contralateral side.</p>
キーワード rat cerebral cortex iron-induced epileptic foces somatosensory evoked potential electrographic discharge
Amo Type Brief Note
発行日 1983-10
出版物タイトル Acta Medica Okayama
37巻
5号
出版者 Okayama University Medical School
開始ページ 447
終了ページ 450
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6650225
Web of Science KeyUT A1983RN98400009
JaLCDOI 10.18926/AMO/32391
フルテキストURL fulltext.pdf
著者 Hattori, Yukio| Moriwaki, Akiyoshi| Yasuhara, Hiromichi| Nishida, Nobuyoshi| Hori, Yasuo|
抄録 <p>A microinjection of ferric chloride solution into the left frontal cortex of rats induced epileptic discharges which were recorded by electrocorticography. In animals having such electrographic seizure activity 30 to 60 days after the injection, the accumulation of cyclic AMP elicited by norepinephrine was examined in slices from four cortical regions. The accumulation was significantly greater in the left anterior area, into which region the ferric chloride solution was injected, than in the right anterior area. There was also a tendency for greater norepinephrine-elicited accumulation of cyclic AMP to occur in the left posterior area than in the right posterior area.</p>
キーワード rat cerebral cortex iron-induced epileptic discharge cortical slices cyclic AMP norepinephrine
Amo Type Brief Note
発行日 1983-08
出版物タイトル Acta Medica Okayama
37巻
4号
出版者 Okayama University Medical School
開始ページ 377
終了ページ 380
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6312769
Web of Science KeyUT A1983RE57600010
JaLCDOI 10.18926/AMO/32390
フルテキストURL fulltext.pdf
著者 Hattori, Yukio| Inaba, Kozo| Moriwaki, Akiyoshi| Nishida, Nobuyoshi| Yasuhara, Hiromichi| Hori, Yasuo|
抄録 <p>An epileptic focus not resulting in generalized convulsions was induced by a microinjection of ferric chloride solution into the left anterior cortex of rats. The formation of the epileptic focus was confirmed by the appearance of bilateral spike and slow wave complexes as well as focal isolated spikes in electrocorticograms (ECoGs). The effect of glutamate on cyclic AMP accumulation was examined in incubated slices prepared from four quadrants of the epileptic cortex. In animals showing isolated spikes 8 to 10 days after the microinjection, the effect of glutamate on cyclic AMP accumulation was stimulatory. It was greatest in the left anterior quadrant which included the injection site, but only slight in the left and right posterior quadrants. In animals showing spike and slow wave complexes 30 to 60 days after the microinjection, the stimulatory effect of glutamate was also most pronounced in the left anterior quadrant. In the right anterior and the left posterior quadrants glutamate had almost no effect, while in the right posterior quadrant, glutamate was inhibitory.</p>
キーワード rat cerebral cortex iron-induced epileptic focus cortical slices glutamate cyclic AMP
Amo Type Article
発行日 1983-08
出版物タイトル Acta Medica Okayama
37巻
4号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 299
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6137941
Web of Science KeyUT A1983RE57600003
JaLCDOI 10.18926/AMO/30345
フルテキストURL fulltext.pdf
著者 Hattori, Yukio| Moriwaki, Akiyoshi| Yasuhara, Hiromichi| Nishida, Nobuyoshi| Hori, Yasuo|
抄録 <p>Ferrous chloride solution was injected unilaterally into the sensorimotor cortex of rats to induce a chronic epileptic focus. Accumulation of cyclic AMP elicited by depolarizing agents was determined in slices from different cortical areas of rats 30-60 days after the injection. In anterior cortical areas which include the sensorimotor cortex, the cyclic AMP accumulation elicited by ouabain or a high concentration of potassium ion was greater in electrographic spike activity on the dominant side than on the other. In posterior cortical areas, no difference in cyclic AMP accumulation was detected. The regional difference in the depolarization-elicited accumulation of cyclic AMP is discussed with regard to the process of epileptic focus.</p>
キーワード cyclic AMP depolarization cortical slices ferrous chloride focal epilepsy rat
Amo Type Brief Note
発行日 1984-10
出版物タイトル Acta Medica Okayama
38巻
5号
出版者 Okayama University Medical School
開始ページ 487
終了ページ 491
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6097100
Web of Science KeyUT A1984TQ61100010