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ID 31332
JaLCDOI
フルテキストURL
著者
Matsui, Hiroaki Okayama Universitry
Rimal, Nirmal Okayama University
Kamakura, Kozue Okayama Univeristy
Uesugi, Seiichiro Okayama Uniiversity
Yamamoto, Hideki Okayama University
Ikeda, Satoru Okayama University
Taketa, Kazuhisa Okayama University
抄録

With advances in lectin affinity electrophoresis of alpha-fetoprotein (AFP), the detection of significant changes in serum AFP at low levels in cirrhotics has become important for early detection of hepatocellular carcinoma. Serum AFP levels of 616 healthy individuals without abnormal liver function tests or virus markers of hepatitis B and C were determined by enzyme immunoassay with IMx-AFP Dainapack using automated IMx apparatus set at twice the ordinary sensitivity and compared with those of 241 individuals with abnormal liver function tests and/or positive hepatitis virus markers. The coefficient of variation in this assay was less than 10% at AFP levels as low as 0.2 ng/ml with a lower detection limit of 0.1 ng/ml. The AFP level of healthy population showed a Gaussian distribution curve after logarithmic transformation with a median and 2.5-97.5 percentile reference range of 2.2 (0.6-5.6) ng/ml. There was no significant difference in the AFP level between males and females. Individuals with abnormal liver function tests alone showed no significant increase in serum AFP unless they were associated with positive hepatitis virus markers.

キーワード
?-fetoprotein
enzyme immunoassay
healthy japanese adults
serum level
reference values
Amo Type
Article
発行日
1998-06
出版物タイトル
Acta Medica Okayama
52巻
3号
出版者
Okayama University Medical School
開始ページ
149
終了ページ
154
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT