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ID 17615
Eprint ID
17615
フルテキストURL
Thumnail 88_459.pdf 8.08 MB
タイトル(別表記)
Studies on membrane architecture of blood corpusclesPart Ⅰ: Ultrastructural study of freeze-etched erythrocyte membranes
著者
多田 慎也 岡山大学医学部大学院医学研究科
抄録
To study the biomembrane architecture, the ultrastructural observation of erythrocyte membranes was performed using the freeze-etching method. Freeze-etched erythrocyte membranes of normal subjects showed the smooth surface with small particles, which were measured 84±23 A in diameter, 3928±182/μ(2) in density in the internal surface (I.S.) and 147±30 A, 643±159/μ(2) in the external surface (E.S.). As the comparative study, the erythrocyte membrane of the patients with autoimmune hemolytic anemia (AIHA), systemic lupus erythematosus (SLE), dyserythroblastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and ovalocytosis were also examined with the freeze-etching method. The erythrocytes showing the functional or morphological abnormalities were proved to have a various type of abnormal architectures in the membranes. In AIHA and PNH, the improvement of anemia was observed after the administration of steroid hormon or vitamin E and was in the good correlation with the normalization of the erythrocyte membrane architecture.
発行日
1976-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
459
終了ページ
476
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/5-6/88_5-6_459/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma