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ID 30784
JaLCDOI
フルテキストURL
著者
Kunisada, Toshiyuki Okayama University
Kawai, Akira Okayama University
Ozaki, Toshifumi Okayama University
Sugihara, Shinsuke Okayama University
Taguchi, Kohji Okayama University Hospital
Inoue, Hajime Okayama University
抄録

In this study, we reviewed the clinical features of 11 patients with malignant schwannoma who were treated in our institute. Five patients had coexistent von Recklinghausen's disease and one of them showed multifocal occurrence. Patients with the centrally located tumors had a poorer prognosis than those with the others. The overall 3-year survival rate was 36%; 40% in patients with von Recklinghausen's disease and 33% in the others. At the time of the last follow-up, 9 patients had died of the tumor, one continued to be tumor free, and one was alive with tumor. Postoperative local recurrence developed in 5 patients (45%); 4 out of 6 patients (67%) who underwent a marginal excision and one out of 3 (33%) who underwent primary amputation. There was no local recurrence in patients after a wide excision with at least 3cm of normal tissue removed surrounding the tumor in all directions. Nine patients (82%) developed pulmonary metastasis. The effect of adjuvant chemotherapy was not clear in this study. The high risk of pulmonary metastasis in this disease indicates the necessity of more effective adjuvant chemotherapy.

キーワード
malignant schwannoma
clinical analysis
von Recklinghausen's disease
Amo Type
Article
発行日
1997-04
出版物タイトル
Acta Medica Okayama
51巻
2号
出版者
Okayama University Medical School
開始ページ
87
終了ページ
92
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT