JaLCDOI 10.18926/AMO/32045
フルテキストURL fulltext.pdf
著者 Tsuboi, Masahiro| Moriya, Yoshio| Tabuchi, Kazuo| Nishimoto, Akira|
抄録 <p>In order to locate the target cells for malignant transformation by BK virus (a human papova virus) in hamster brain, electron microscopic observation of tumor originally induced in hamster brain by BK virus was performed. With light microscopy, the BK virus-induced tumor (Vn 17) bore a close resemblance to human malignant ependymoma. Under the electron microscope, numerous microvilli and few cilia were visible on the surface of the tumor cells. These tumor cells were joined to each other by desmosomes. Gap junctions were not observed. Multilayered cuboidal cells were observed around the lumen and blood vessels in the tumor. With regard to fine structure, three types of Vn 17 cells were recognized; ependymal like cells, tanycytes with prominent cell processes, and undifferentiated cells with few cytoplasmic organelles. There was no basal lamina between the ependymal cells and the connective tissue stroma. The Vn 17 cells showed some similarity to the ultrastructural features of the epemdymal cells of newborn rabbits, suggesting that the target cells for Vn 17 may be cells related to ependyma. Malignant transformation of the cells would be initiated in the early stages after BK virus inoculation into the brain of newborn hamsters.</p>
キーワード elevtron microscopy experimental brain tumor BK virus
Amo Type Article
発行日 1979-12
出版物タイトル Acta Medica Okayama
33巻
6号
出版者 Okayama University Medical School
開始ページ 423
終了ページ 430
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 231894
NAID 120002312316
JaLCDOI 10.18926/AMO/31150
フルテキストURL fulltext.pdf
著者 Tabuchi, Kazuo|
抄録 <p>A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at death were 15.1 days and 4.1 mm in diameter respectively. The consistency of the days of death after intracranial transplantation of the tumor was remarkable. The transplanted tumors developed preferentially at the site of implantation and tumor cell seeding and tumor growing took place rarely along the ventricular system. Glial or lymphoid cell response to the tumor was not observed at any stage after transplantation in surrounding cerebral tissues of the animals. Histomorphologically, no elementary differences were observed between intracranially transplanted tumors and serially transplanted subcutaneous tumors. These facts permit the system to be applied to an experimental brain tumor model as large-scale testing.</p>
Amo Type Article
発行日 1971-12
出版物タイトル Acta Medicinae Okayama
25巻
6号
出版者 Okayama University Medical School
開始ページ 605
終了ページ 613
NCID AA00041342
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4264054
NAID 120002312718
JaLCDOI 10.18926/AMO/30670
フルテキストURL fulltext.pdf
著者 Harada, Yasuhiro| Tabuchi, Kazuo| Moriya, Yoshio| Furuta, Tomohisa| Kishikawa, Hidemi| Nishimoto, Akira|
抄録 <p>The amount of S-100 protein in rat brain embolized with carbon microspheres decreased in parallel with the development of cerebral edema as judged by water content, recovering to the normal range by 24h after embolization. These results suggest the participation of S-100 protein in the permeability characterisitics of nervous system capillaries known as the blood-brain barrier.</p>
キーワード S-100 protein blood-brain barrier cerebral edema
Amo Type Article
発行日 1982-12
出版物タイトル Acta Medica Okayama
36巻
6号
出版者 Okayama University Medical School
開始ページ 447
終了ページ 451
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7158426
Web of Science KeyUT A1982PW07500003
JaLCDOI 10.18926/AMO/30542
フルテキストURL fulltext.pdf
著者 Miyamoto, Kanji| Miyano, keiko| Tabuchi, Kazuo| Nishimoto, Akira| Yoshida, Haruhiko| Yumoto, Tokichi| Tanaka, Toshio|
抄録 Chromosome studies of a malignant lymphoma cell line derived from the brain were made by Q- and G-banding techniques. The modal number of chromosomes was 45. Complex structural rearrangements were present, but the 14q+ marker chromosome frequently seen in malignant lymphomas was not identified in the cell line. The main karyotype in cells analyzed was 45, X, -Y, del (2) (q21q23), t (3;?) (p25;?), t (p12;?), -8, 11q+, 18q+, +mar. Absence of the 14q+ may be explained by: firstly, clones which possessed 14q+ marker chromosome in brain tumor cells may have been selected out with increasing culture time and repeated passages; or secondly, the presence of the 14q+ marker chromosome depends on the type of lymphoma.
キーワード brain lymphoma tissue culture cell line chromosome negative 14q+.
Amo Type Brief Note
発行日 1980-04
出版物タイトル Acta Medica Okayama
34巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 122
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6450513
Web of Science KeyUT A1980JY15600005