ID | 30827 |
フルテキストURL | |
著者 |
Taguchi, Hirokuni
Okayama University
Stafford, Denise M.
Northwick Park Hospital
Chanarin, Israel
Northwick Park Hospital
|
抄録 | Deoxyuridine suppression tests have been performed by two different methods of six normoblastic and eight megaloblastic marrows. A good correlation was obtained between the results by the modified and the original methods. The simplified method was found to be applicable for a clinical purpose to diagnose megaloblastosis in the marrow. Uptake of 3H-deoxyuridine into DNA and effect of various concentrations of thymidine was studied on five normoblastic and six megaloblastic marrows. In megaloblastic marrows, a greater amount of thymidine was required to obtain the same rate of suppression of 3H-deoxyuridine incorporation into DNA than in normoblastic marrows. Impairment of thymidine incorporation into DNA in megaloblastic marrows was not revealed. Therefore, lower rate of suppression of 3H-deoxyuridine by thymidine in megaloblastic marrows may be due to impairment of the incorporation of deoxyuridine before the addition of thymidine. |
発行日 | 1977-04
|
出版物タイトル |
Acta Medica Okayama
|
巻 | 31巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
English
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Amo Type | Article
|
Submission Path | amo/vol31/iss2/3
|