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ID 32289
JaLCDOI
フルテキストURL
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著者
Karatas, Yusuf Cukurova University
Ergun, Yusuf Cukurowa University
Gocmen, Cemil Cukurova University
Secilmis, Ata Cukurova University
Singirik, Ergin Cukurova University
Dikmen, Atilla Cukurova University
Bayasal, Firuz Cukurowa University
抄録

The present study was undertaken to investigate the postsynaptic effects of aminoglycosides on contractions evoked by acetylcholine (ACh), KCl, electrical field stimulation (EFS) and Na(+)- and Ca(2+)-free Ringer solution with 0.2 mM Na2 EDTA (NaFCaFR) in the isolated frog rectus abdominis. Neomycin inhibited contraction elicited by ACh, NaFCaFR, and EFS at the higher frequencies (8 and 10 Hz) but not those elicited by KCl and EFS at the lower frequencies (2, 3 and 5 Hz). D-tubocurarine inhibited ACh-induced contractions in a concentration-dependent manner. In addition, drug reduced EFS-evoked contractions to a limited extent. Lower concentrations (10(-5), 5 x 10(-5), 10(-4), 2 x 10(-4) and 3 x 10(-4) M) but not higher concentrations (4 x 10(-4) and 5 x 10(-4) M) of methoxyverapamil exhibited a concentration-dependent inhibitory action on NaFCaFR-induced contractions. Similar inhibitions of the same type of contraction were displayed by aminoglycosides (neomycin, streptomycin, netilmycin, gentamycin and amikacin). These results suggest that in addition to their antagonistic action on nicotinic receptors in the frog rectus abdominis, aminoglycosides may exert stabilizing effects on some functional components contributing to contractions at the membrane.

キーワード
aminoglycoside
voltage sensor
sodium and calcium free Ringer solution
frog rectus abdominis
contoraction
Amo Type
Article
発行日
2000-04
出版物タイトル
Acta Medica Okayama
54巻
2号
出版者
Okayama University Medical School
開始ページ
49
終了ページ
56
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT