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ID 32273
JaLCDOI
フルテキストURL
著者
Ucar, Peyman Cukurova University
Gocmen, Cemil Cukurova University
Secilmis, Ata Cukurova University
Karatas, Yusuf Cukurova University
Singirik, Ergin Cukurova University
Onder, Serpil Cukurova University
Dikmen, Atilla Cukurova University
Baysal, Firuz Cukurova University
抄録

The applications of ultraviolet (UV) light (336 nm) on the upper oesophageal strips of frog elicited relaxant responses in the presence of NaNO2 (50 microM). The tissues were mounted under the tension 0.5 g in an organ bath containing Ringer solution, maintained at 25 degrees C and gassed with 100% O2. The responses were recorded on a kymograph via an isotonic lever. Antimegaloblastic agents, including hydroxocobalamin (1, 10, and 100 microM), cyanocobalamin (1, 10, 25, and 100 microM), and folic acid (1, 10, 50, 100, and 200 microM), significantly attenuated the relaxation response to UV light. Folinic acid (1, 10, 25, and 100 microM), however, enhanced the relaxation. Pyrogallol (50 microM), hydroquinone (50 microM), and diethyldithiocarbamic acid (8 mM) were found ineffective for attenuation, though FeSO4 (200, 400, and 500 microM) and hemoglobin (50 microM), respectively, exerted significant inhibition. L-arginine methylester (500 microM) did not impair UV-induced relaxation. Based on these results, we concluded that a mechanism involving undefined action(s) of antimegaloblastic drugs may cause alterations in the UV light-induced relaxation of the tissue used.

キーワード
ultraviolet light
frog oesophageal strip
hydroxocobalamin
cyanocobalamin
folic acid
Amo Type
Article
発行日
2000-08
出版物タイトル
Acta Medica Okayama
54巻
4号
出版者
Okayama University Medical School
開始ページ
147
終了ページ
152
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT