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ID 32834
JaLCDOI
フルテキストURL
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著者
Dirlik, Musa Mersin University
Buyukafsar, Kansu Mersin University
Cinel, Ismail Mersin University
Cinel, Leyla Mersin University
Caglikulekci, Mehmet Mersin University
Tamer, Lulufer Mersin University
Aydin, Suha Mersin University
Oral, Ugur Mersin University
抄録

Effect of ornithine which is known to inhibit L-arginine uptake via cationic amino acid transport system has been tested, and compared to aminoguanidine, an iNOS inhibitor in lypopolysaccharide (LPS)-induced endotoxemia in rats. Serum nitrite/nitrate and malondialdehyde (MDA) level have been measured, and ileal histology has also been examined. Endotoxin increased serum nitrite/nitrate and MDA levels from 15.7+/- 2.4 micromol/ml and 2.1 +/-0.2 nmol/ml to 23.1 +/- 1.0 micromol/ml and 5.2+/- 0.3 nmol/ml (both P<0.05), respectively. In addition, LPS caused ileal degeneration. L-ornithine (500 mg/kg) did not improve septic manifestations, i.e., serum nitrite/nitrate and MDA levels did not differ from those in endotoxemia. Neither does it have an improving action on ileal histology. However, higher dose of L-ornithine (2,500 mg/kg) lowered the increased level of nitrite/nitrate and MDA by LPS. Moreover, it restored ileal histology from grade 3 (median) to 0 (median) (P<0.05). On the other hand, aminoguanidine (100 mg/kg) normalized serum nitrite/nitrate and MDA levels but not ileal histology in endotoxemic rats. In conclusion, high dose of L-ornithine could improve endotoxemic parameters in LPS-treated rats.

キーワード
LPS
ornithine
aminoguanidine
endotoxemia
lipid peroxidation
Amo Type
Article
発行日
2003-06
出版物タイトル
Acta Medica Okayama
57巻
3号
出版者
Okayama University Medical School
開始ページ
117
終了ページ
122
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT