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ID 30398
JaLCDOI
フルテキストURL
著者
Moriyama, Masahiro Okayama University
Domoto, Haruyo Okayama University
Yamashita, Syoichi Okayama University
Furuno, Katsushi Okayama University
Oishi, Ryozo Kyushu University
Kawasaki, Hiromu Okayama University
Gomita, Yutaka Okayama University
抄録

We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.

キーワード
phenobarbital
pharmacokinetics
pregnancy
plasma concentrations
Amo Type
Article
発行日
1995-10
出版物タイトル
Acta Medica Okayama
49巻
5号
出版者
Okayama University Medical School
開始ページ
237
終了ページ
240
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT