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ID 50657
フルテキストURL
著者
Kobayashi, Sayo Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol
Nouso, Kazuhiro Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol
Kinugasa, Hideaki
Takeuchi, Yasuto
Tomoda, Takeshi
Miyahara, Koji
Hagihara, Hiroaki
Kuwaki, Kenji
Onishi, Hideki Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol
Nakamura, Shinichiro
Ikeda, Fusao Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol
Miyake, Yasuhiro
Shiraha, Hidenori
Takaki, Akinobu
Yamamoto, Kazuhide
抄録
Aim: Hepatocellular carcinoma (HCC) is a common clinical problem all over the world. Fucosylated hemopexin (Fuc-Hpx) is a newly reported glycoprotein for the diagnosis of HCC, however, its clinical implications are unclear. The aim of this study was to elucidate the clinical utility of Fuc-Hpx in Japanese patients with HCC. Methods: The sera from 331 HCC patients, 45 with liver cirrhosis (LC), 85 with chronic hepatitis (CH) and 22 healthy people were examined for the expression of Fuc-Hpx; the level was compared with clinical parameters as well as hemopexin (Hpx) expression. The expressions of Fuc-Hpx in 12 HCC tissues and corresponding adjacent non-cancerous liver tissues were also examined. Results: No correlation was observed between Hpx and Fuc-Hpx level. The median Fuc-Hpx levels in healthy people and CH, LC and HCC patients were 3.8, 3.7, 6.1 and 7.6 AU/mL, respectively (CH vs LC, P = 0.002; CH vs HCC, P < 0.001; LC vs HCC, P = 0.02). Multivariate analysis revealed that low albumin, low prothrombin time and the presence of HCC were significantly correlated with high Fuc-Hpx (P = 0.013, =0.001 and <0.001, respectively). Among the HCC patients, albumin was correlated with high Fuc-Hpx; however, none of the tumor factors, such as tumor size, tumor number and tumor stage, was correlated with Fuc-Hpx level. The expression of Fuc-Hpx in cancer tissue was not different from that in non-cancerous tissue. Conclusion: Fuc-Hpx is a valuable biomarker for HCC but it might be a marker for hypercarcinogenic liver rather than a marker for tumor-bearing liver.
キーワード
biomarker
fucosylated hemopexin
glycosylation
hepatocellular carcinoma
hypercarcinogenicity
発行日
2012-12
出版物タイトル
Hepatology Research
42巻
12号
出版者
Wiley-Blackwell
開始ページ
1187
終了ページ
1195
ISSN
1386-6346
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1111/j.1872-034X.2012.01044.x
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/50669
言語
English
論文のバージョン
author
査読
有り
DOI
Web of Sience KeyUT