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ID 16220
Eprint ID
16220
フルテキストURL
Thumnail 96_87.pdf 1.28 MB
タイトル(別表記)
Effect of coronary sinus occlusion on coronary circulation and hemodynamics Part 1. Effect of coronary sinus occlusion on coronaryhemodynamics and incidence of ventricular fibrillationduring acute myocardial ischemia in dogs
著者
西山 修 岡山大学医学部癌研生化学
抄録
The effect of coronary sinus (CS) occlusion produced with a specially designed balloon catheter on coronary hemodynamics and ischemia-induced ventricular fibrillation was studied in anesthetized open-chest dogs. Heart rate (HR), aortic blood pressure (BP), left ventricular max dp/dt, coronary blood flow (CBF) and cardiac output decreased slightly with coronary sinus occlusion, while left ventricular end-diastolic pressure was not affected. These changes were attenuated but did not disappear, by pre-treatment with atropine. This result suggests that, at least partly, these changes were direct effects of venous congestion in the ventricular wall. CBF decreased in the diastolic, but increased in the systolic phase. Coronary sinus pressure (CSP) markedly increased especially in systole after CS occlusion, resulting in a pressure pattern resembling the left ventricular pressure pattern. The CSP exceeded the left ventricular pressure in the diastolic phase. Peak flow, reactive hyperemia flow, and repayment after a brief coronary artery occlusion were all decreased. Myocardial O(2) extraction increased by about 9%, and the increase correlated well with the elevation of mean CSP. When the left anterior descending coronary artery was occluded, CS-occlusion increased retrograde pressure from 22±4mmHg to 33±7mmHg, and the incidence of ventricular fibrillation was decreased. Washout of the metabolites by retrograde flow from the ischemic myocardium would seem to be responsible for this reduction of ventricular fibrillation.
キーワード
冠静脈洞閉鎖
反応性充血
逆行性血圧
心室細動
心筋酸素摂取率
発行日
1984-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
96巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
87
終了ページ
99
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/96/1-2/96_1-2_87/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma