JaLCDOI 10.18926/AMO/56067
フルテキストURL 72_3_223.pdf
著者 Ida, Jun| Kotani, Kazuhiko| Miyoshi, Toru| Nakamura, Kazufumi| Kohno, Kunihisa| Asonuma, Hirohiko| Sakuragi, Satoru| Doi, Masayuki| Miki, Takashi| Koyama, Yasushi| Ito, Hiroshi|
抄録 Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0<CAC progression ≦100; 7.7%, and CAC progression >100; 23.6%). Logistic regression analysis showed that Lp(a) > 30 mg/dL was an independent predictor of the annual change in Agatston score > 100 (OR: 5.51; 95% CI: 1.28-23.68; p=0.02), even after adjusting for age, sex, hypertension, diabetes mellitus, current smoking, body mass index, and lipid-lowering medications. Baseline Lp(a) >30 mg/dL was a predictor of CAC progression in this population of patients with hypercholesterolemia undergoing statin therapy.
キーワード lipoprotein(a) coronary artery calcification statins hypercholesterolemia
Amo Type Original Article
発行日 2018-06
出版物タイトル Acta Medica Okayama
72巻
3号
出版者 Okayama University Medical School
開始ページ 223
終了ページ 230
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29925999
JaLCDOI 10.18926/AMO/55656
フルテキストURL 72_1_1.pdf
著者 Saito, Yukihiro| Nakamura, Kazufumi| Ito, Hiroshi|
抄録 The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy.
キーワード cell therapy pluripotent stem cells cardiomyocytes biological pacemaker hyperpolarization activated cyclic nucleotide gated potassium channel 4
Amo Type Review
発行日 2018-02
出版物タイトル Acta Medica Okayama
72巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 7
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29463932
フルテキストURL J_Cardiology_70_1_23.pdf Fig.pdf
著者 Tachibana, Motomi| Nishii, Nobuhiro| Morimoto, Yoshimasa| Kawada, Satoshi| Miyoshi, Akihito| Sugiyama, Hiroyasu| Nakagawa, Koji| Watanabe, Atsuyuki| Nakamura, Kazufumi| Morita, Hiroshi| Ito, Hiroshi|
キーワード Implantable cardioverter-defibrillator Sudden cardiac death Ventricular arrhythmia
備考 This is an Accepted Manuscript of an article published by Elsevier
発行日 2017-07
出版物タイトル Journal of Cardiology
70巻
1号
出版者 Japanese College of Cardiology
開始ページ 23
終了ページ 28
ISSN 0914-5087
NCID AN10070473
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 28034575
DOI 10.1016/j.jjcc.2016.11.014
Web of Sience KeyUT 000408601100004
関連URL isVersionOf https://doi.org/10.1016/j.jjcc.2016.11.014
フルテキストURL Vasc_Health_Risk_Manag_11_265.pdf
著者 Saito, Yukihiro| Nakamura, Kazufumi| Akagi, Satoshi| Sarashina, Toshihiro| Ejiri, Kentaro| Miura, Aya| Ogawa, Aiko| Matsubara, Hiromi| Ito, Hiroshi|
キーワード apoptosis prostacyclin pulmonary arterial hypertension
備考 学位審査副論文
発行日 2015-05-14
出版物タイトル Vascular Health and Risk Management
11巻
出版者 Dove Medical Press
開始ページ 265
終了ページ 270
ISSN 1176-6344
NCID AA12158664
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 25999730
DOI 10.2147/VHRM.S50368
Web of Sience KeyUT 000210424400027
関連URL https://doi.org/10.2147/VHRM.S50368 http://ousar.lib.okayama-u.ac.jp/55246