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ID 14101
Eprint ID
14101
フルテキストURL
Thumnail 106_573.pdf 5.7 MB
タイトル(別表記)
Ferritin in human erythroid cells : With references to transferrin receptor and stainable iron at maturation
著者
花房 純弘 岡山大学医学部第二内科学教室
抄録
To measure the intracellular ferritin (Ft) content in human erythroid cells, a new method was developed using human bone marrow amears. With this method, Ft, transferrin receptors (TfR) and stainable iron granules (SIG) were semiquantified at the single cell level and the cell's maturation level was identified. The relationship between Ft and other parameters was investigatted. Ft-H subunit concentrations were found to decrease with maturation from basophilic to orthochromatic erythroblasts (r=-0.62,p<0.05) and further decreased after denucleation. There was significant positive correlation between the Ft-H subunit concentra-tion and TfR density (r=0.52,p<0.01), but the relation between the Ft-L subunit and TfR or the density of SIG was obscure. These data indicate that : 1) The Ft-H subunit might play a more important role than the Ft-L subunit during iron metabolism and differentiation of erythroid cells. 2) Some factors other than intracellular iron levl, such as maturation, seem to play important roles in the Ft expression in erythroid cells.
キーワード
ferritin
erythroid cell
transferrin receptor
non-hemin iron
備考
原著
発行日
1994
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
573
終了ページ
585
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_573/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma