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ID 17447
Eprint ID
17447
フルテキストURL
Thumnail 90_1117.pdf 575 KB
タイトル(別表記)
Studies on pathophysiology and treatment in patients with active acromegaly Part I. Studies on pathophysiology of active acromegaly
著者
花房 学 岡山大学医学部第三内科
抄録
The effects of several drugs on the release of human growth hormone (hGH) were investigated, and the following results were obtained. 1). Single intravenous injection of insulin or drop infusion of L-arginine provocated an increase in plasma hGH in 3 out of 8 and 4 out of 6 patients with active acromegaly, respectively. 2). Single intravenous injection of thyrotropin-releasing hormone (TRH) or luteinizing hormone-releasing hormone (LH-RH) provoked a prompt increase in plasma hGH in 7 out of 13 and 4 out of 10 patients with acromegaly, respectively, whereas no significant change in plasma hGH was observed in normal subjects. 3). Plasma hGH levels decreased significantly within 30 min after an injection of glucagon in 7 out of 10 patients with acromegaly. 4). Single oral administration of L-dopa or 2-Br-α-ergocryptine (CB-154) induced a significant fall in hGH levels in patients with acromegaly, but a significant rise in plasma hGH in normal subjects. 5). The hGH response to L-dopa was compared before and after incomplete removal of pituitary adenoma in 2 patients with active acromegaly. Before surgery L-dopa decreased the plasma hGH levels, while after surgery L-dopa caused a significant increase in plasma hGH levels in both patients. At 10 months after surgery L-dopa decreased the plasma hGH levels again in one patient despite a low basal hGH concentration. These results suggest that the primary disorder of the acromegaly resides in the pituitary level at least in some patients with acromegaly.
発行日
1978-10-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
90巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1117
終了ページ
1128
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/90/9-10/90_9-10_1117/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma