JaLCDOI 10.18926/AMO/31561
フルテキストURL fulltext.pdf
著者 Hamazaki, Heisuke| Kato, Tomohiro| Yunoki, Yasuhiro| Mori, Masanobu| Gochi, Akira| Mimura, Hisashi| Orita, Kunzo|
抄録 <p>To determine whether a relationship exists between DNA ploidy and the prognosis of hepatocellular carcinoma (HCC), flow cytometric DNA analysis was performed in paraffin-embedded specimens obtained from 44 patients with HCC who underwent hepatectomy. There were 26 diploid (59%) and 18 aneuploid (41%) tumors. No correlation was shown between DNA ploidy pattern and patient age, sex, liver cirrhosis, hepatitis B virus antigen and serum alpha-fetoprotein level. The ploidy pattern had no significant correlation with the presence of vascular invasion or intrahepatic metastasis. Only Edmondson's grade was well correlated with the ploidy pattern. We noted a significant correlation between survival rates and the presence of vascular invasion or intrahepatic metastasis (p &#60; 0.05). In contrast, no significant correlation was found between DNA ploidy pattern and the prognosis of HCC. The results of this study indicate that DNA ploidy pattern may not be a useful indicator for the prognosis of HCCs after hepatic resection, unlike the results of gastric and colon cancers. </p>
キーワード DNA ploidy pattern hepatocellular carcinoma hepatic resection prognosis
Amo Type Article
発行日 1993-12
出版物タイトル Acta Medica Okayama
47巻
6号
出版者 Okayama University Medical School
開始ページ 413
終了ページ 416
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8128916
Web of Sience KeyUT A1993MP00700009