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ID 57150
フルテキストURL
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著者
Koyama, Takahisa Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kariya, Shin Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Sato, Yasuharu Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Gion, Yuka Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Higaki, Takaya Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Haruna, Takenori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fujiwara, Tazuko Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Minoura, Akira Department of Public Health, Showa University School of Medicine
Takao, Soshi Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Orita, Yorihisa Department of Otolaryngology-Head and Neck Surgery, Kumamoto University
Kanai, Kengo Department of Otorhinolaryngology-Head & Neck Surgery, Kagawa Prefectural Central Hospital
Taniguchi, Masami Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
Nishizaki, Kazunori Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Okano, Mitsuhiro Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
Background: IgG4 production is regulated by type 2 (IL-4 and IL-13) and regulatory (IL-10) cytokines involved in the pathophysiology of chronic rhinosinusitis (CRS). We sought to determine the pathophysiological characteristics of IgG4-positive cells in sinonasal tissues in CRS, especially eosinophilic CRS (ECRS).
Methods: IgG4-positive cells in uncinate tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. Associations between the number of IgG4-positive cells and clinicopathological factors were analyzed. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of IgG4-positive cells in tissue that can predict the post-operative course.
Results: IgG4 was mainly expressed in infiltrating plasma and plasmacytoid cells, and the number of IgG4-positive cells was significantly higher in NP, especially those from severe ECRS patients, than in UT. In CRS patients, the number of IgG4-positive cells significantly and positively correlated with blood and tissue eosinophilia, radiological severity, and serum level of total IgE. The number of infiltrating IgG4-positive cells was significantly higher in patients with a poor post-operative course (sustained sinus shadow 6 months after surgery) than in those with a good one. The number of IgG4-positive cells in NP could discriminate patients with a good or a poor post-operative course (area under the curve: 0.769). Also, 73.3% sensitivity and 82.5% specificity were achieved when the cut-off value was set at 17 cells/high-power field.
Conclusions: Our results suggest that the local expression of IgG4 on cells may be used as a biomarker that reflects the pathophysiology of CRS, including the post-operative course.
キーワード
Chronic rhinosinusitis
Eosinophils
IgG4
Nasal polyps
Severity
発行日
2019-04-30
出版物タイトル
Allergology International
68巻
2号
出版者
Elsevier
開始ページ
216
終了ページ
224
ISSN
13238930
NCID
AA11091750
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン
publisher
PubMed ID
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.alit.2018.09.002
ライセンス
http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
Takahisa Koyama, Shin Kariya, Yasuharu Sato, Yuka Gion, Takaya Higaki, Takenori Haruna, Tazuko Fujiwara, Akira Minoura, Soshi Takao, Yorihisa Orita, Kengo Kanai, Masami Taniguchi, Kazunori Nishizaki, Mitsuhiro Okano, Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis, Allergology International, Volume 68, Issue 2, 2019, Pages 216-224, ISSN 1323-8930, https://doi.org/10.1016/j.alit.2018.09.002.
助成機関名
日本学術振興会
助成番号
16K15721
17K16920
オープンアクセス(出版社)
OA
オープンアーカイブ(出版社)
非OpenArchive