フルテキストURL EBioMedicine_2017_154.pdf
著者 Kunisada, Yuki| Eikawa, Shingo| Tomonobu, Nahoko| Domae, Shohei| Uehara, Takenori| Hori, Shohei| Furusawa, Yukihiro| Hase, Koji| Sasaki, Akira| Udono, Heiichiro|
キーワード Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR
発行日 2017-10-16
出版物タイトル EBioMedicine
25巻
出版者 Elsevier Science
開始ページ 154
終了ページ 164
ISSN 23523964
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 © 2017 The Authors.
論文のバージョン publisher
PubMed ID 29066174
DOI 10.1016/j.ebiom.2017.10.009
Web of Science KeyUT 000417440500026
関連URL isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009
JaLCDOI 10.18926/AMO/55204
フルテキストURL 71_3_219.pdf
著者 Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
抄録  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
キーワード oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
発行日 2017-06
出版物タイトル Acta Medica Okayama
71巻
3号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 226
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28655941