フルテキストURL GGI_16_4_440.pdf fig.pdf
著者 Tokuchi, Ryo| Hishikawa, Nozomi| Matsuzono, Kosuke| Takao, Yoshiki| Wakutani, Yosuke| Sato, Kota| Kono, Syoichiro| Ohta, Yasuyuki| Deguchi, Kentaro| Yamashita, Toru| Abe, Koji|
抄録 AIM: The aim of the present study was to compare the effects of a galantamine only therapy and a combination therapy with galantamine plus ambulatory cognitive rehabilitation for Alzheimer's disease patients. METHODS: For this retrospective cohort study, we enrolled 86 patients with Alzheimer's disease, dividing them into two groups - a galantamine only group (group G, n = 45) and a combination with galantamine plus ambulatory rehabilitation group (group G + R, n = 41). The present cognitive rehabilitation included a set of physical therapy, occupational therapy and speech therapy for 1-2 h once or twice a week. We compared the Mini-Mental State Examination and Frontal Assessment Battery for cognitive assessment, and Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia score for affective assessment in two groups over 6 months. RESULTS: The baseline Mini-Mental State Examination score was 20.2 and 18.7 in groups G and G + R, respectively. Other baseline data (Frontal Assessment Battery, Geriatric Depression Scale, Apathy Scale, and Abe's Behavioral and Psychological Symptoms of Dementia) were not different between the two groups. Although group G kept all the scores stable until 6 months of the treatment, the Apathy Scale score showed a significant improvement in group G + R as early as 3 months, followed by the Mini-Mental State Examination and Frontal Assessment Battery improvements at 6 months (*P = 0.04 and *P = 0.02, respectively). The Geriatric Depression Scale and Abe's Behavioral and Psychological Symptoms of Dementia did not show any changes. CONCLUSION: The combination therapy of galantamine plus ambulatory cognitive rehabilitation showed a superior benefit both on cognitive and affective functions than galantamine only therapy in Alzheimer's disease patients.
キーワード Alzheimer's disease affective function cognitive function combination therapy galantamine
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2016-04
出版物タイトル Geriatrics & Gerontology International
16巻
4号
出版者 Japan Geriatrics Society
開始ページ 440
終了ページ 445
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25952367
DOI 10.1111/ggi.12488
Web of Sience KeyUT 000373611800005
関連URL isVersionOf https://doi.org/10.1111/ggi.12488
フルテキストURL GGI_16_4_458.pdf
著者 Hishikawa, Nozomi| Fukui, Yusuke| Sato, Kota| Kono, Syoichiro| Yamashita, Toru| Ohta, Yasuyuki| Deguchi, Kentaro| Abe, Koji|
抄録 AIMS: The world is rapidly aging, and is facing an increase of late-elderly dementia patients. It is important to investigate the characteristic features of late-elderly dementia in a super-aged country. METHODS: We examined 1554 patients with cognitive decline in Department of Neurology, Okayama University Hospital, Okayama, Japan, divided into three subgroups according to the age: young-elderly (age ≤64 years), middle-elderly (age 65-74 years) and late-elderly (age 75 years), and investigated the cognitive, affective and activities of daily living functions (ADL), especially in late-elderly patients compared with young-elderly and middle-elderly patients. RESULTS: Among 1554 patients, Alzheimer's disease dominated at 62%, and age-dependently increased up to 69% in the late-elderly group. The total scores of four cognitive tests were significantly worse with aging for specific subscales of orientation, recall, visual retention, word fluency and so on. In contrast, total scores of the affective tests showed only an increase in the apathy scale in the late-elderly group. Each subgroup showed depressive/depression in 63.2-55.2%, and apathy in 44.2-54.8%. Furthermore, instrumental ADL items significantly deteriorated in the late-elderly group, which statistically correlated with Mini-Mental State Examination score. CONCLUSIONS: These results show that the late-elderly group is characterized by significant cognitive declines, increasing apathy, and instrumental ADL decrease. The cognitive decline may be related to such affective and ADL declines.
キーワード affective functions cognitive function daily living function late-elderly dementia super-aged country
備考 This is an Accepted Manuscript of an article published by Wiley
発行日 2016-04
出版物タイトル Geriatrics & Gerontology International
16巻
4号
出版者 Japan Geriatrics Society
開始ページ 458
終了ページ 465
ISSN 1444-1586
NCID AA1155729X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン author
PubMed ID 25952646
DOI 10.1111/ggi.12492
Web of Sience KeyUT 000373611800007
関連URL isVersionOf https://doi.org/10.1111/ggi.12492
JaLCDOI 10.18926/AMO/55311
フルテキストURL 71_4_341.pdf
著者 Yamazaki, Kenji| Wakabayashi, Hiroshi| Suganami, Yu| Sano, Shinichi| Wakunami, Yu| Katayama, Takashi| Deguchi, Kentaro| Nagotani, Shoko| Kishida, Masayuki|
抄録 We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.
キーワード dermatomyositis anti-melanoma differentiation-associated gene 5 antibody interstitial lung disease pneumomediastinum
Amo Type Case Report
発行日 2017-08
出版物タイトル Acta Medica Okayama
71巻
4号
出版者 Okayama University Medical School
開始ページ 341
終了ページ 344
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28824190