JaLCDOI 10.18926/AMO/31509
フルテキストURL fulltext.pdf
著者 Hamaya, Kazuo| Doi, Kenji| Tanaka, Toshio| Nishimoto, Akira|
抄録 <p>Glial fibrillary acidic protein (GFAP) was purified from human spinal cord and cerebral white matter. GFAP was localized by an immuno-peroxidase method in normal adult and fetal human brains, rat brains, and 152 central nervous system (CNS) tumors. GFAP was found in reactive and normal astrocytes, immature cells of fetal brain at the 18th to 21st gestational weeks, and normal rat astrocytes. This GFAP staining was quite specific for glial tumors, including astrocytomas, glioblastomas, astroblastomas, and ependymomas. GFAP-positive cells were also found in oligodendrogliomas and choroid plexus papillomas, and they were interpreted as being astroglial or ependymal differentiations. Stromal cells in cerebellar hemangioblastomas were negative. However, engulfed astrocytes were found at the periphery of such tumors and often adjacent to the proliferate blood vessels. In meningiomas, neurinomas, metastatic carcinomas, pituitary adenomas and other non-glial tumors, GFAP-positive cells were not identified.</p>
キーワード glial librillary acidic protein central nervous system tumors
Amo Type Article
発行日 1985-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 453
終了ページ 462
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4091041
Web of Science KeyUT A1985AWT4000005