JaLCDOI 10.18926/AMO/32906
フルテキストURL fulltext.pdf
著者 Mukai, Takashi| Mimura, Hidefumi| Gobara, Hideo| Takemoto, Mitsuhiro| Himei, Kengo| Hiraki, Takao| Hase, Soichiro| Fujiwara, Hiroyasu| Iguchi, Toshihiro| Tajiri, Nobuhisa| Sakurai, Jun| Yasui, Kotaro| Sano, Yoshifumi| Date, Hiroshi| Kanazawa, Susumu|
抄録 We report the clinical experience of radiofrequency ablation followed by radiation therapy for large primary lung tumors. Two patients with large primary lung tumors were treated with combined radiofrequency ablation and radiation therapy, and good local control was observed. Combined radiofrequency ablation and radiation therapy that involves minimally invasive techniques appears to be promising for the treatment of large lung tumors.
キーワード radiofrequency ablation lung cancer radiation therapy
Amo Type Case Report
発行日 2007-06
出版物タイトル Acta Medica Okayama
61巻
3号
出版者 Okayama University Medical School
開始ページ 177
終了ページ 180
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol61/iss3/8
PubMed ID 17593954
Web of Sience KeyUT 000247574700008
JaLCDOI 10.18926/AMO/32891
フルテキストURL fulltext.pdf
著者 Yuasa, Ichiro| Tsukuda, Kazunori| Hirai, Ryuji| Ota, Tetsuya| Murakami, Masakazu| Naito, Minoru| Doihara, Hiroyoshi| Date, Hiroshi| Shimizu, Nobuyoshi|
抄録 <p>Resection is the only curative treatment for liver metastasis of colorectal cancers. Despite the supreme regenerative potential of the liver, major hepatectomy sometimes leads to liver failure, and the limitation of resectable liver volumes makes advanced tumors inoperable. This study was attempted to promote liver regeneration using hepatocyte growth factor (HGF) gene transfection by venous-administered adenovirus and to improve the survival of rats after massive hepatectomy. The adenovirus that encodes HGF was administered to rats before 85%-hepatectomy. The administration of HGF gene improved the survival of rats after massive hepatectomy, while the administration of control adenovirus deteriorated their survival. Gene transfection of HGF showed up-regulation of serum HGF, stimulation of hepatocellular proliferation and rapid liver regeneration. Moreover, HGF administration reduced apoptosis of hepatocytes. The administration of HGF gene prevented liver dysfunction after major hepatectomy and may be a new assist for surgery.</p>
キーワード gene therapy hepatectomy HGF adenoviral vector
Amo Type Original Article
発行日 2007-04
出版物タイトル Acta Medica Okayama
61巻
2号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 88
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol61/iss2/5
PubMed ID 17471308
Web of Sience KeyUT 000245875600005
JaLCDOI 10.18926/AMO/32673
フルテキストURL fulltext.pdf
著者 Ichiba, Shingo| Okabe, Kazunori| Date, Hiroshi| Shimizu, Nobuyoshi| Teramoto, Shigeru|
抄録 <p>Extracorporeal Membrane Oxygenation (ECMO) has been adopted as a means of strong respiratory support. In lung transplantation, reimplantation response is still a serious problem. It causes severe respiratory failure which is refractory to mechanical ventilation in some cases. The purpose of this study was to evaluate the effects of veno-venous ECMO after lung transplantation using a canine autotransplantation model. The autotransplantation model was created by keeping the left lung in a warm ischemic state for 2 h. After reperfusion, the right pulmonary artery was ligated. The following two groups were studied: Group 1, Control group, (no ECMO group) (n = 6). After reperfusion, both lungs were ventilated without ECMO. Group 2, ECMO group (n = 7). After reperfusion, veno-venous ECMO support was introduced with reduction of mechanical ventilation. In the no ECMO group, four of the animals died within 210 min after reperfusion. In the ECMO group, two of the animals died of severe pulmonary edema. Data of blood gas analyses (PaO2, PaCO2, and SvO2) after reperfusion were significantly better in the ECMO group, whereas there were no significant differences in both shunt fraction and pulmonary vascular resistance index. In this model with severe pulmonary edema induced by warm ischemia, veno-venous ECMO contributed to the improvement of hypoxemia and hypercapnia, but did not improve pulmonary hemodynamics.</p>
キーワード extracorporeal membrance oxygenation(ECMO) warm ischemia reimplantation response lung transplantation pulmonary edema veno-venous ECMO
Amo Type Article
発行日 1992-06
出版物タイトル Acta Medica Okayama
46巻
3号
出版者 Okayama University Medical School
開始ページ 213
終了ページ 221
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol46/iss3/10
PubMed ID 1502926
Web of Sience KeyUT A1992JB50400010
JaLCDOI 10.18926/AMO/32657
フルテキストURL fulltext.pdf
著者 Andou, Akio| Maruyama, Shuichirou| Matsutani, Takahiro| Date, Hiroshi| Shimizu, Nobuyoshi| Teramoto, Shigeru|
抄録 <p>Trans-sternal bilateral thoracotomy was performed to resect the right upper lobe and the left S1 + 2 + S3, and to complete lymphadenectomy in a 35-year-old female case of lung cancer in whom multiple lesions were suspected. Trans-sternal bilateral thoracotomy was considered to be useful for one-stage surgery in patients in whom bilateral lung cancer is suspected or confirmed, because it provides a sufficient surgical field enabling the resection of lung and lymph nodes. This may be the first case report of trans-sternal bilateral thoracotomy to treat multiple primary lung cancer.</p>
キーワード trans-sternal bilateral thoracotomy lung cancer
Amo Type Article
発行日 1992-10
出版物タイトル Acta Medica Okayama
46巻
5号
出版者 Okayama University Medical School
開始ページ 395
終了ページ 399
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol46/iss5/11
PubMed ID 1442159
Web of Sience KeyUT A1992JX49500011
JaLCDOI 10.18926/AMO/32619
フルテキストURL fulltext.pdf
著者 Shimizu, Nobuyoshi| Yamashita, Motohiro| Date, Hiroshi| Ando, Akio| Teramoto, Shigeru|
抄録 <p> We performed pulmonary artery angioplasty in 19 patients with lung cancer. The procedure consists of segmental or wedge resrection of the infiltrated pulmonary artery stem followed by reconstruction to avoid pneumonectomy and preserve pulmonary function. Among these cases &#34;double sleeve resection&#34; was performed in 10 cases. The 5-year survival of the angioplasty patients was poor at a rate of 11&#65285;, but not significantly different from the survival rates for those patients who underwent bronchoplasy alone or pneumonectomy. A promising prognosis may be expected in cases with N0 and N1 lymph node metastasis. However, this procedure may not replace pneumonectmy in patients with intact pulmonary function.</p>
キーワード lung cancer surgery vascular invasion bronchoplastry
Amo Type Article
発行日 1992-08
出版物タイトル Acta Medica Okayama
46巻
4号
出版者 Okayama University Medical School
開始ページ 303
終了ページ 311
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol46/iss4/12
Web of Sience KeyUT A1992JL44200011
JaLCDOI 10.18926/AMO/32116
フルテキストURL fulltext.pdf
著者 Kurose, Taichi| Okumura, Yoshihiro| Sato, Shuhei| Yamamoto, Yasuhiro| Akaki, Shiro| Takeda, Yoshihiro| Kanazawa, Susumu| Ando, Akio| Date, Hiroshi| Shimizu, Nobuyoshi| Hiraki, Yoshio|
抄録 <p>We evaluated the respiratory functions of patients with pulmonary emphysema who underwent lung volume reduction surgery (LVRS) by the mean transit time (MTT) with Xe-133 lung ventilation scintigraphy, forced expiration volume in 1 sec (FEV1.0), residual volume (RV), distance walked in 6 min (6-min walk), and the Hugh-Jones classification (H-J classification) before and after LVRS. In 69 patients with pulmonary emphysema (62 men, 7 women; age range, 47-75 years; mean age, 65.4 years +/- 6.1, preoperative H-J classification, III (two were II)-V) who underwent LVRS, all preoperative and postoperative parameters (MTT 3 weeks after LVRS and the others 3 months after LVRS) were judged statistically by the Wilcoxon signed-ranks test and Odds ratio. Every postoperative parameter was improved with a significant difference (P &#60; 0.05) compared to preoperative parameters. MTT at 3 weeks after LVRS was not associated with %FEV1.0 and the H-J classification at 3 months after LVRS, but was associated with RV and a 6-min walk at 3 months after LVRS. MTT was useful for the clinical evalution of aerobic capability after LVRS.</p>
キーワード lung volume reduction surgery (LVRS) respiratory functions Xe-133 lung ventilation scintigraphy pulmonary emphysema
Amo Type Article
発行日 2004-02
出版物タイトル Acta Medica Okayama
58巻
1号
出版者 Okayama University Medical School
開始ページ 7
終了ページ 15
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol58/iss1/2
PubMed ID 15157006
Web of Sience KeyUT 000189271100002
JaLCDOI 10.18926/AMO/31605
フルテキストURL fulltext.pdf
著者 Date, Hiroshi| Andou, Akio| Shimizu, Nobuyoshi| Teramoto, Shigeru| Numata, Takeyuki|
抄録 <p>Ten radiograph signs were assessed by two experts for their usefulness in the diagnosis of small solitary peripheral pulmonary nodules less than 3 cm. The ten categories included notching, spicula formation, pleural indentation, vascular convergence, contour, paleness, homogeneity, cavitation, air bronchogram, and calcification. The cases included 134 lung cancers and 44 benign lung lesions resected between 1972 and 1988 at the Second Department of Surgery, Okayama University Medical School. Notching, spicula formation, pleural indentation, vascular convergence, contour, and air bronchogram were useful signs in differentiating lung cancer from benign lung lesions. However, since the radiograph signs exhibited great variation in both lung cancer and benign lung lesions, a diagnostic operation is sometimes inevitable.</p>
キーワード lung cancer pulmonary nodule notching spicula pleural indentation
Amo Type Article
発行日 1993-02
出版物タイトル Acta Medica Okayama
47巻
1号
出版者 Okayama University Medical School
開始ページ 53
終了ページ 57
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol47/iss1/9
PubMed ID 8460555
Web of Sience KeyUT A1993KP18500009
JaLCDOI 10.18926/AMO/31600
フルテキストURL fulltext.pdf
著者 Andou, Akio| Shimizu, Nobuyoshi| Maruyama, Shuichirou| Makihara, Yoshiki| Date, Hiroshi| Teramoto, Shigeru|
抄録 <p>A case illustrating the value of aggressive respiratory training in improving the prognosis of lung cancer complicated by low pulmonary function is reported. Preoperative and postoperative respiratory training enabled the patient with chronic respiratory failure to survive a lengthy operation and eventually breathe without assistance. The patient has survived more than 71 months, and experiences only exertional dyspnea at the time of publication. Aggressive preoperative and postoperative respiratory management may make more of the growing number of lung cancer patients eligible for standard surgical procedures.</p>
キーワード lung cancer low pulmonary function respiratory training
Amo Type Article
発行日 1993-02
出版物タイトル Acta Medica Okayama
47巻
1号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 71
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol47/iss1/12
PubMed ID 8460558
Web of Sience KeyUT A1993KP18500012
JaLCDOI 10.18926/AMO/31579
フルテキストURL fulltext.pdf
著者 Kayano, Koichi| Date, Hiroshi| Uno, Koji| Shimizu, Nobuyoshi| Teramoto, Shigeru|
抄録 <p>We evaluated the viability of the cadaver lung and the effect of lung inflation with 100% oxygen using a canine allotransplantation model. Donor animals were killed by potassium chloride (KCl) injection and were kept at room temperature until lung extraction. The animals were divided into the following 3 groups: group 1 (n = 6) in which the donor lungs were retrieved 2h after sacrifice, group 2 (n = 6) in which the donor lungs were retrieved 3h after sacrifice, and group 3 (n = 6) in which the donor lungs were retrieved 3h after sacrifice as in group 2 except that they were kept inflated for 3h with 100% oxygen using a double lumen endotracheal tube. Heparin was not given and lungs were not flushed with preservation solution. After left lung transplantation, the transplanted lung function including gas exchange and pulmonary hemodynamics was assessed for 6h by ligating the right pulmonary artery of the recipient animals. All 6 animals in groups 1 and 3 survived for 6 h with excellent lung function. Only 2 of 6 animals in group 2 survived for 6h with poor lung function. These results led us to conclude the following: a) the cadaver lung kept at room temperature for 2h might be available for lung transplantation, and b) when the cadaver lung is inflated with 100% oxygen, the length of safe ischemic time could be prolonged up to 3h.</p>
キーワード cadaver lung single lung transplantation ?lung inflation
Amo Type Article
発行日 1993-10
出版物タイトル Acta Medica Okayama
47巻
5号
出版者 Okayama University Medical School
開始ページ 329
終了ページ 337
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol47/iss5/7
PubMed ID 8273456
Web of Sience KeyUT A1993ME47100007
JaLCDOI 10.18926/AMO/31559
フルテキストURL fulltext.pdf
著者 Maruyama, Shuichirou| Sano, Yoshifumi| Date, Hiroshi| Shimizu, Nobuyuki| Teramoto, Shigeru|
抄録 <p>Early diagnosis of rejection and timely immunosuppression are absolutely important in clinical lung transplantation. We studied surface markers of peripheral blood lymphocytes (PBL), graft infiltrating lymphocytes (GIF) and bronchoalveolar lavage fluid (BALF) in a rat using flow cytometric monitoring to diagnose rejection. Left lung transplantation was performed on Brown Norway (BN) rats and Lewis (LEW) rats in the following groups; Group 1: LEW-LEW (isograft), Group 2: BN-LEW (allograft; no immunosuppression), Group 3: BN-LEW (allograft; treated with Cyclosporine A at a dose of 15 mg/kg/day i.m.). In each group, rats were killed 3, 5, 7 days postoperatively (n = 6 on each day). Monoclonal antibodies investigated in this study were W3/25 (anti-helper T lymphocyte), OX8 (anti-suppressor/cytotoxic T lymphocyte), and OX39 (anti-interleukin 2 receptor). Histological classification of rejection in Group 2 showed vascular phase at 3 days, alveolar phase at 5 days, and destructive phase at 7 days, respectively. No evidence of rejection was found in Group 1 or 3. In Group 2, W3/25 positive cell proportion in GIL and BALF significantly decreased as the rejection progressed, but OX8 positive and OX39 positive cell proportion increases were significantly greater than in Groups 1 and 3 as the rejection progressed. These results lead us to speculate that the studies of T cell subsets in GIL and BALF lymphocytes are useful for diagnosis of rejection in lung transplantation.</p>
キーワード lung transplantation rejection lymphocyte subsets flow cytometry BALF
Amo Type Article
発行日 1993-12
出版物タイトル Acta Medica Okayama
47巻
6号
出版者 Okayama University Medical School
開始ページ 399
終了ページ 406
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol47/iss6/7
PubMed ID 8128914
Web of Sience KeyUT A1993MP00700007
JaLCDOI 10.18926/AMO/30991
フルテキストURL fulltext.pdf
著者 Okutani, Daisuke| Yamane, Masaomi| Toyooka, Shinichi| Oto, Takahiro| Aoe, Motoi| Sano, Yoshifumi| Date, Hiroshi|
抄録 <p>Dry pleural dissemination in non-small cell lung cancer, defined as solid pleural metastasis of lung cancer without pleural eff usion, is a condition occurring in T4 lung cancer. Positron emission tomography (PET) has been reported to be useful for the diagnosis and staging of lung cancer. It has been reported that positive findings on PET scans of indeterminate pleural abnormalities at computed tomography (CT) are sensitive to malignancy. We encountered two cases of dry small pleural dissemination of adenocarcinoma of the lung preoperatively detected by PET/CT. A 75-year-old man and a 66-year-old man underwent CT scan, which demonstrated solitary tumor in the lung, an enlarged mediastinal lymph node, and a small pleural nodule less than 10 mm in size, all of which were positive findings on the fluorine 18 fluorodeoxyglucose (FDG) PET portion of an integrated PET/CT. Both patients underwent thoracoscopic biopsy of the dry pleural nodule revealing dissemination of adenocarcinoma of the lung (T4). Whereas histological thoracoscopic diagnosis remains mandatory before planning treatment, our cases may suggest that PET/CT will be useful as a screening modality for dry pleural dissemination of lung cancer.</p>
キーワード non-small cell lung cancer pleural dissemination positron emission tomography PET/CT
Amo Type Case Report
発行日 2008-02
出版物タイトル Acta Medica Okayama
62巻
1号
出版者 Okayama University Medical School
開始ページ 55
終了ページ 58
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss1/8
PubMed ID 18323864
Web of Sience KeyUT 000253549500008
JaLCDOI 10.18926/AMO/30990
フルテキストURL fulltext.pdf
著者 Toyooka, Shinichi| Kishimoto, Takumi| Date, Hiroshi|
抄録 <p>Malignant mesothelioma (MM) is a highly aggressive tumor with a dismal prognosis. The incidence of MM is increasing as a result of widespread exposure to asbestos. As for the molecular alterations that occur in MM, chromosome alterations including homo-deletion of the P16 and P14 genes located in the 9p21 are well known. Mutations are rare in the P53 and Ras genes, which are frequently present in epithelial solid tumors. However, mutations are frequently present in the neurofi bromatosis type 2 gene. Epigenetic alterations including DNA methylation have been found in the MM, the profi le of which is diff erent from that of lung cancer, although differential diagnosis is sometimes clinically difficult. As in other malignant tumors, genes that are related to immortalization, proliferation, metastasis, angiogenesis, and anti-apoptosis are also overexpressed in MM, contributing to its malignant phenotype. It is of interest that simian virus 40 has been implicated to be one of the causative factors of MM in western countries. Although the causative role of asbestos is well-known in MM, much less information is available for MM than for other malignant tumors regarding the molecular alterations that occur in the disease. In terms of future tasks, it will be necessary to apply the knowledge that is learned about molecular alterations to clinical practice and to further elucidate the pathogenesis of MM with extensive research.</p>
キーワード malignant mesothelioma P16 methylation
Amo Type Review
発行日 2008-02
出版物タイトル Acta Medica Okayama
62巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 7
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss1/1
PubMed ID 18323865
Web of Sience KeyUT 000253549500001
JaLCDOI 10.18926/AMO/30969
フルテキストURL fulltext.pdf
著者 Osaragi, Tomohiko| Nagahiro, Itaru| Miyaguchi, Naoyuki| Mori, Hideaki| Sano, Yoshifumi| Date, Hiroshi| Shimizu, Nobuyoshi|
抄録 <p>The aim of this study was to determine the optimal temperature of graft preservation after ex vivo gene transfer to rat lung isografts. Left lungs were harvested and infused with cationic lipid/LacZ-DNA complex via the pulmonary artery, and the grafts were stored for 4h. The grafts (n=7) were allocated into groups IンIV according to the storage temperature:4℃, 10℃, 16℃, and 23℃, respectively. Forty-eight h after orthotopic transplantation, the arterial blood gas was analyzed and the peak airway pressure (PAP) and the level of LacZ protein production in the grafts were measured by reverse transcription polymerase chain reaction. After reperfusion, the grafts were stained with hematoxylin and eosin. The grafts in groups III and IV showed more deterioration as evidenced by decreased arterial oxygen tension, increased PAP, and predominant infiltration of inflammatory cells compared with groups I and II. The level of LacZ production was significantly lower in group I than in groups IIンIV. The optimal temperature of lung graft preservation after ex vivo gene transfer was determined to be 10℃, balancing considerations of lung injury and efficiency of transgene expression.</p>
キーワード lung transplantation gene transfection optimal temperature organ preservation
Amo Type Original Article
発行日 2008-10
出版物タイトル Acta Medica Okayama
62巻
5号
出版者 Okayama University Medical School
開始ページ 297
終了ページ 302
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン publisher
査読 有り
Submission Path amo/vol62/iss5/3
PubMed ID 18985089
Web of Sience KeyUT 000260391300003