JaLCDOI 10.18926/AMO/30398
フルテキストURL fulltext.pdf
著者 Moriyama, Masahiro| Domoto, Haruyo| Yamashita, Syoichi| Furuno, Katsushi| Oishi, Ryozo| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.</p>
キーワード phenobarbital pharmacokinetics pregnancy plasma concentrations
Amo Type Article
発行日 1995-10
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 237
終了ページ 240
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8585393
Web of Science KeyUT A1995TC51800002